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. 2021 Feb 10:10:549982.
doi: 10.3389/fonc.2020.549982. eCollection 2020.

The Prognostic and Predictive Significance of circRNA CDR1as in Tumor Progression

Fang Jian  1 , Ren Yangyang  2 , Xu Wei  1 , Xu Jiadan  3 , Li Na  1 , Yang Peng  1 , Bian Maohong  1 , Niu Guoping  4 , Pan Zhaoji  4
Affiliations

The Prognostic and Predictive Significance of circRNA CDR1as in Tumor Progression

Fang Jian et al. Front Oncol. .

Abstract

Cerebellar degeneration-related protein 1 antisense (CDR1as) is an important member of the circRNAs family, also known as cirs-7. Its main function in vivo is to act as a mir-7 sponge. Accumulated studies show that CDR1as is closely related to various diseases, especially cancer. Our analysis show that CDR1as expression in human cancer is significantly associated with poor overall survival (hazard ratio [HR] = 2.50, 95% confidence interval [CI] = 2.06-3.04; p < 0.00001) and that high CDR1as expression is associated with the tumor node metastasis stage (odds ratio [OR] = 2.13, 95% CI = 1.63-2.78; p < 0.00001), and distant metastasis (OR = 3.50, 95% CI = 1.90-6.64; p < 0.00001). Furthermore, the results reveal the prognostic significance of CDR1as in neoplasms of the digestive system (HR = 1.69, 95% CI = 2.14-2.71; p < 0.001), colorectal cancer (HR = 1.34, 95% CI = 1.96-2.85; p < 0.001), and non-small cell lung cancer (HR = 2.40, 95% CI = 3.42-4.83; p = 0.008). In this study, we summarize in detail the latest research findings and demonstrate the function and regulatory mechanism of CDR1as in various cancer processes, and its potential as a biomarker for cancer prevention and prognosis.

Keywords: cancer; cerebellar degeneration-related protein 1 antisense; function; predictive significance; prognostic.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Mechanism of CDR1as in various cancers. (A–C) CDR1as regulates the signaling pathways of HCC, NSCLC, and CRC processes. (D) CDR1as regulates the signaling pathways of ESCC processes. (E) CDR1as regulates the signaling pathways of other cancers.
Figure 2
Figure 2
Forest plot of the hazard ratio (HR) for CDR1as increase and overall survival.
Figure 3
Figure 3
High expression of CDR1as indicates poor prognosis of tumor.
Figure 4
Figure 4
High expression of CDR1as is related to the clinicopathology of tumor.
See this image and copyright information in PMC

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