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. 2021 Feb 16:8:624092.
doi: 10.3389/fpubh.2020.624092. eCollection 2020.

Economic Value of Lost Productivity Attributable to Human Papillomavirus Cancer Mortality in the United States

Masoom Priyadarshini  1 , Vimalanand S Prabhu  2 , Sonya J Snedecor  1 , Shelby Corman  1 , Barbara J Kuter  2 , Chizoba Nwankwo  2 , Diana Chirovsky  2 , Evan Myers  3
Affiliations

Economic Value of Lost Productivity Attributable to Human Papillomavirus Cancer Mortality in the United States

Masoom Priyadarshini et al. Front Public Health. .

Erratum in

Abstract

Objectives: To estimate years of potential life lost (YPLL) and present value of future lost productivity (PVFLP) associated with premature mortality due to HPV-attributable cancers, specifically those targeted by nonavalent HPV (9vHPV) vaccination, in the United States (US) before vaccine use. Methods: YPLL was estimated from the reported number of deaths in 2017 due to HPV-related cancers, the proportion attributable to 9vHPV-targeted types, and age- and sex-specific US life expectancy. PVFLP was estimated as the product of YPLL by age- and sex-specific probability of labor force participation, annual wage, value of non-market labor, and fringe benefits markup factor. Results: An estimated 7,085 HPV-attributable cancer deaths occurred in 2017 accounting for 154,954 YPLL, with 5,450 deaths (77%) and 121,226 YPLL (78%) attributable to 9vHPV-targeted types. The estimated PVFLP was $3.3 billion for cancer deaths attributable to 9vHPV-targeted types (86% from women). The highest productivity burden was associated with cervical cancer in women and anal and oropharyngeal cancers in men. Conclusions: HPV-attributable cancer deaths are associated with a substantial economic burden in the US, much of which could be vaccine preventable.

Keywords: cervical cancer; human papillomavirus; mortality; oropharyngeal cancer; productivity loss.

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Conflict of interest statement

VP, BK, CN, and DC are employees of Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA, who may own stock and/or hold stock options in Merck & Co., Inc., Kenilworth, NJ, USA. MP, SS, and SC are employees of Pharmerit – an OPEN Health Company, paid consultants to Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA. The remaining author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Cancer deaths by age and sex in the United States in 2017: HPV-associated cancers. HPV, human papillomavirus.
See this image and copyright information in PMC

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