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Meta-Analysis
. 2021 Jun;53(5):e14034.
doi: 10.1111/and.14034. Epub 2021 Mar 5.

Association between human papillomavirus infection and sperm quality: A systematic review and a meta-analysis

Shangren Wang  1 , Li Liu  1 , Aiqiao Zhang  2 , Yuxuan Song  1 , Jiaqi Kang  1 , Xiaoqiang Liu  1
Affiliations
Meta-Analysis

Association between human papillomavirus infection and sperm quality: A systematic review and a meta-analysis

Shangren Wang et al. Andrologia. 2021 Jun.

Abstract

Human papillomavirus (HPV) has a high incidence rate in both males and females. HPV infection in women has been shown to affect fertility and lead to foetal death and pregnancy loss. However, research on HPV infection in men is limited. The aim of this study was to study the effect of HPV infection in semen on sperm quality and present the findings of previous studies through a meta-analysis. Databases including PubMed, MEDLINE, EMBASE, Web of Science, Cochrane Library, WanFang data and China National Knowledge Infrastructure were searched for relevant studies. A systematic review and meta-analysis were performed, and 17 studies were included for analyses based on a set criterion. Meta-analyses indicated that HPV infection in semen significantly reduced sperm concentration (SMD = -0.12, 95% CI: -0.21 to -0.03, p = .009), sperm motility (SMD = -0.55, 95% CI: -0.780 to -0.33, p = .000), sperm viability (SMD = -0.55, 95% CI: -0.780 to -0.33, p = .000) and sperm morphology (SMD = -0.34, 95% CI: -0.61 to -0.07, p = .015). The high-risk HPV (HrHPV) infection could significantly reduce sperm count (SMD = -0.65, 95% CI: -1.11 to -0.18, p = .007) compared with high-risk HPV (LrHPV) infection. In conclusion, HPV infection in semen significantly reduced sperm quality, and the HrHPV infection could significantly reduce sperm count compared with LrHPV.

Keywords: human papillomavirus infection; meta-analysis; sperm quality; systematic review.

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References

REFERENCES

    1. Adams, J. A., Galloway, T. S., Mondal, D., Esteves, S. C., & Mathews, F. (2014). Effect of mobile telephones on sperm quality: A systematic review and meta-analysis. Environment International, 70, 106-112. https://doi.org/10.1016/j.envint.2014.04.015
    1. Boeri, L., Capogrosso, P., Ventimiglia, E., Pederzoli, F., Cazzaniga, W., Chierigo, F., Pozzi, E., Clementi, M., Viganò, P., Montanari, E., Montorsi, F., & Salonia, A. (2019). High-risk human papillomavirus in semen is associated with poor sperm progressive motility and a high sperm DNA fragmentation index in infertile men. Human Reproduction, 34(2), 209-217. https://doi.org/10.1093/humrep/dey348
    1. Brossfield, J. E., Chan, P. J., Patton, W. C., & King, A. (1999). Tenacity of exogenous human papillomavirus DNA in sperm washing. Journal of Assisted Reproduction and Genetics, 16(6), 325-328. https://doi.org/10.1023/a:1020458100382
    1. Chrysostomou, A. C., Stylianou, D. C., Constantinidou, A., & Kostrikis, L. G. (2018). Cervical cancer screening programs in Europe: The transition towards HPV vaccination and population-based HPV testing. Viruses, 10(12), 729. https://doi.org/10.3390/v10120729
    1. Clifford, G. M., Rana, R. K., Franceschi, S., Smith, J. S., Gough, G., & Pimenta, J. M. (2005). Human papillomavirus genotype distribution in low-grade cervical lesions: Comparison by geographic region and with cervical cancer. Cancer Epidemiology, Biomarkers & Prevention, 14(5), 1157-1164. https://doi.org/10.1158/1055-9965.EPI-04-0812

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