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Comment
. 2021 Jul;74(1):515-518.
doi: 10.1002/hep.31790. Epub 2021 May 22.

Macrophage Heterogeneity in NASH: More Than Just Nomenclature

Gopanandan Parthasarathy  1 , Harmeet Malhi  1
Affiliations
Comment

Macrophage Heterogeneity in NASH: More Than Just Nomenclature

Gopanandan Parthasarathy et al. Hepatology. 2021 Jul.
No abstract available

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Conflict of interest statement

Potential conflict of interest: Nothing to report.

Figures

FIG. 1.
FIG. 1.
Heterogeneity of monocyte-derived macrophages in NASH. In a mouse model of NAFLD, resident yolk sac-embryonic KCs are gradually lost, and this niche is subsequently repopulated by BM-derived monocytes. The resulting intrahepatic macrophage population is heterogeneous, consisting of many subsets including pre-monocyte-derived KCs and hepatic LAMs. Hepatic LAMs express osteopontin, are located in fibrotic zones, and possess a unique transcriptomic profile. What signals drive the differentiation of monocyte-derived KCs into hepatic LAMs is unclear. Whereas hepatic LAMs had a distinct ability to metabolize lipid compared to KCs, whether this has significance in their crosstalk with steatotic hepatocytes is also undefined.
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