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Meta-Analysis
. 2021 May;70(5):509-524.
doi: 10.1007/s00011-021-01448-z. Epub 2021 Mar 5.

Association of IL-10 -1082A>G, -819C>T, and -592C>A polymorphisms with susceptibility to chronic and aggressive periodontitis: a systematic review and meta-analysis

Fatemeh Mashhadiabbas  1 , Seyed Alireza Dastgheib  2 , Ahmad Hashemzehi  3 , Zahra Bahrololoomi  4 , Fatemeh Asadian  5 , Hossein Neamatzadeh  6   7 , Masoud Zare-Shehneh  6 , Karim Daliri  2
Affiliations
Meta-Analysis

Association of IL-10 -1082A>G, -819C>T, and -592C>A polymorphisms with susceptibility to chronic and aggressive periodontitis: a systematic review and meta-analysis

Fatemeh Mashhadiabbas et al. Inflamm Res. 2021 May.

Abstract

Objectives: Several epidemiological studies have evaluated association of interleukin 10 (IL-10) polymorphisms with risk of periodontitis. However, the results remain conflicting and inconclusive. Here, we carried out a comprehensive systematic review and meta-analysis to evaluate the association of IL-10 -1082A>G, -819C>T, and -592C>A polymorphisms with risk of chronic (CP) and aggressive (CP) periodontitis.

Methods: Electronic databases including PubMed, Science Direct, SciELO, and CNKI were systematically searched to identify all relevant studies published up to 01 June 2020.

Results: A total of 60 case-control studies with 5313 cases and 6528 controls met our inclusion criteria. Overall, the pooled data showed that the IL-10 -592C>A polymorphism was statistically associated with increased risk of periodontitis in the overall population, while no significant association was identified for IL-10 -1082A>G and IL-10 -819C>T polymorphisms. The subgroup analysis by ethnicity revealed that the IL-10 -1082A>G polymorphism was significantly associated with periodontitis risk in Caucasians, IL-10 -819C>T polymorphism in mixed population, and IL-10 -592C>A polymorphism in both Asians and mixed populations. When further analyzed by periodontitis type, only the IL-10 -592C>A polymorphism was associated with CP risk, but not AgP; and the IL-10 -1082A>G and -819C>T polymorphisms have not positive association neither in the CP and AgP.

Conclusions: The current meta-analysis showed that the IL-10 -592C>A polymorphism was statistically associated with periodontitis risk in the overall population. Moreover, the IL-10 -1082A>G, IL-10 -819C>T, and IL-10 -592C>A polymorphisms were associated with periodontitis risk by ethnicity. Therefore, the IL-10 polymorphisms are of high clinical relevance by ethnicity and would be a useful marker to identify patients who are at higher risk for periodontitis.

Keywords: Aggressive; Chronic; Interleukin-10; Meta-analysis; Periodontitis; Polymorphism.

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References

    1. Nazir MA. Prevalence of periodontal disease, its association with systemic diseases and prevention. Int J Health Sci. 2017;11:72–80.
    1. Radwan-Oczko M, Dus-Ilnicka I, Richards P, Thomsen AM, Rasmussen C. Evaluation of oral health status and oral care of patients with rheumatoid arthritis. Int J Dent. 2020;2020:8896766. https://doi.org/10.1155/2020/8896766 .
    1. Otomo-Corgel J, Pucher JJ, Rethman MP, Reynolds MA. State of the science: chronic periodontitis and systemic health. J Evid Based Dent Pract. 2012;12:20–8. - PubMed
    1. Kaur G, Grover V, Bhaskar N, Kaur RK, Jain A. Periodontal Infectogenomics. Inflamm Regen. 2018;38:8–25. - PubMed - PMC
    1. Saini R, Marawar PP, Shete S, Saini S. Periodontitis, a true infection. J Glob Infect Dis. 2009;1:149–50. - PubMed - PMC

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