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Comment
. 2021 Mar 4;28(3):359-361.
doi: 10.1016/j.stem.2021.02.018.

Myeloproliferative Neoplasms: The Long Wait for JAK2-Mutant Clone Expansion

Damien Luque Paz  1 , Peter Ashcroft  2 , Radek C Skoda  3
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Myeloproliferative Neoplasms: The Long Wait for JAK2-Mutant Clone Expansion

Damien Luque Paz et al. Cell Stem Cell. .
Free article

Abstract

Myeloproliferative neoplasms (MPNs) are hematological malignancies caused by somatic mutations originating from a single hematopoietic stem cell (HSC). In this issue of Cell Stem Cell,Van Egeren et al. (2021) used whole-genome sequencing of hematopoietic colonies to reconstruct the clonal history and time of acquisition of the disease-initiating gene mutation.

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Conflict of interest statement

Declaration of interests R.C.S. has consulted for and received honoraria from BMS/Celgene and Novartis. D.L.P. and P.A. declare no competing interests.

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