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Comment
. 2021 Mar 4;28(3):361-363.
doi: 10.1016/j.stem.2021.02.021.

Stabilizing Formative Pluripotent States with Germ Cell Competency

Ng Shyh-Chang  1 , Lei Li  2
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Stabilizing Formative Pluripotent States with Germ Cell Competency

Ng Shyh-Chang et al. Cell Stem Cell. .
Free article

Abstract

Previous work demonstrating the existence of intermediate pluripotency states in post-implantation embryos had ignited a debate on whether "formative" pluripotency can be stabilized in pluripotent stem cell (PSC) lines. In this issue of Cell Stem Cell, two papers show that polarized epithelial and germ cell-competent formative PSCs can be maintained in modified activin-dependent conditions.

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Conflict of interest statement

Declaration of Interests N.S-C. is a member of the Joint Steering Committee of the Ferring Institute of Reproductive Medicine, a research institute jointly funded by Ferring Pharmaceuticals and the Chinese Academy of Sciences to advance basic and translational research in reproductive medicine.

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