How to make a better T cell: in vivo CRISPR screens have some answers

Matteo Villa¹, Michal A Stanczak¹, Erika L Pearce²

Affiliations

¹ Department of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.
² Department of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany; The Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, MD 21287, USA. Electronic address: epearce6@jhmi.edu.

PMID: 33667366
DOI: 10.1016/j.cell.2021.02.003

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How to make a better T cell: in vivo CRISPR screens have some answers

Matteo Villa et al. Cell. 2021.

Free article

. 2021 Mar 4;184(5):1135-1136.

doi: 10.1016/j.cell.2021.02.003.

Authors

Matteo Villa¹, Michal A Stanczak¹, Erika L Pearce²

Affiliations

¹ Department of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.
² Department of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany; The Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, MD 21287, USA. Electronic address: epearce6@jhmi.edu.

PMID: 33667366
DOI: 10.1016/j.cell.2021.02.003

Abstract

Understanding what regulates CD8⁺ T cell responses is key to effectively harnessing these cells in human disease. In this issue of Cell, Huang et al. and Chen et al. use in vivo CRISPR screens to discover novel regulators of CD8⁺ T cell immunity to engineer a more efficacious response against cancer and infections.

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Conflict of interest statement

Declaration of Interests E.L.P. is an SAB member of Immunomet, a Founder and Advisor of Rheos Medicines, and an Advisory Board member of Cell. A family member of E.L.P. is a Founder and Advisor of Rheos Medicines.

Comment on

In vivo CD8⁺ T cell CRISPR screening reveals control by Fli1 in infection and cancer.
Chen Z, Arai E, Khan O, Zhang Z, Ngiow SF, He Y, Huang H, Manne S, Cao Z, Baxter AE, Cai Z, Freilich E, Ali MA, Giles JR, Wu JE, Greenplate AR, Hakeem MA, Chen Q, Kurachi M, Nzingha K, Ekshyyan V, Mathew D, Wen Z, Speck NA, Battle A, Berger SL, Wherry EJ, Shi J. Chen Z, et al. Cell. 2021 Mar 4;184(5):1262-1280.e22. doi: 10.1016/j.cell.2021.02.019. Epub 2021 Feb 25. Cell. 2021. PMID: 33636129 Free PMC article.
In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8⁺ T cell fate decisions.
Huang H, Zhou P, Wei J, Long L, Shi H, Dhungana Y, Chapman NM, Fu G, Saravia J, Raynor JL, Liu S, Palacios G, Wang YD, Qian C, Yu J, Chi H. Huang H, et al. Cell. 2021 Mar 4;184(5):1245-1261.e21. doi: 10.1016/j.cell.2021.02.021. Epub 2021 Feb 25. Cell. 2021. PMID: 33636132 Free PMC article.

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How to make a better T cell: in vivo CRISPR screens have some answers

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How to make a better T cell: in vivo CRISPR screens have some answers

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Conflict of interest statement

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