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Comment
. 2021 Mar 4;184(5):1139-1141.
doi: 10.1016/j.cell.2021.02.005.

A vicious cycle in atherosclerosis

Aldons J Lusis  1
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A vicious cycle in atherosclerosis

Aldons J Lusis. Cell. .
Free article

Abstract

Clonal hematopoiesis, defined as the presence of expanded somatic blood cell clones, is associated with about a doubling in the risk of coronary heart disease in humans. Heyde and colleagues now provide evidence that clonal hematopoiesis results largely from increased stem cell proliferation, which is, in turn, stimulated by atherosclerosis.

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  • Increased stem cell proliferation in atherosclerosis accelerates clonal hematopoiesis.
    Heyde A, Rohde D, McAlpine CS, Zhang S, Hoyer FF, Gerold JM, Cheek D, Iwamoto Y, Schloss MJ, Vandoorne K, Iborra-Egea O, Muñoz-Guijosa C, Bayes-Genis A, Reiter JG, Craig M, Swirski FK, Nahrendorf M, Nowak MA, Naxerova K. Heyde A, et al. Cell. 2021 Mar 4;184(5):1348-1361.e22. doi: 10.1016/j.cell.2021.01.049. Epub 2021 Feb 25. Cell. 2021. PMID: 33636128 Free PMC article.

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