Struggle for survival: new insights into NELF condensation for adaptive transcriptional reprogramming
- PMID: 33667379
- DOI: 10.1016/j.molcel.2021.02.008
Struggle for survival: new insights into NELF condensation for adaptive transcriptional reprogramming
Abstract
In this issue of Molecular Cell, Rawat et al. (2021) characterize novel stress-induced condensates of the negative elongation factor (NELF) as the nuclear counterparts of cytosolic stress granules. This provides a new perspective on transcription repression orchestrated by phase separation.
Copyright © 2021 Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of Interests The authors declare no competing interests. P.L. is a member of the advisory board of Molecular Cell.
Comment on
-
Stress-induced nuclear condensation of NELF drives transcriptional downregulation.Mol Cell. 2021 Mar 4;81(5):1013-1026.e11. doi: 10.1016/j.molcel.2021.01.016. Epub 2021 Feb 5. Mol Cell. 2021. PMID: 33548202 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
