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. 2021 Mar 4;81(5):901-904.
doi: 10.1016/j.molcel.2021.02.018.

No pains, no gains: how chromosome fragmentation promotes gene amplification

Cheng-Zhong Zhang  1
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No pains, no gains: how chromosome fragmentation promotes gene amplification

Cheng-Zhong Zhang. Mol Cell. .
Free article

Abstract

Combining live-cell imaging, cytogenetics, genome sequencing, and in vitro evolution, Shoshani et al. (2020) revealed deep connections between chromothripsis, the catastrophic shattering of a chromosome in abnormal nuclear structures, and gene amplification, a frequent culprit of oncogenic activation.

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  • Chromothripsis drives the evolution of gene amplification in cancer.
    Shoshani O, Brunner SF, Yaeger R, Ly P, Nechemia-Arbely Y, Kim DH, Fang R, Castillon GA, Yu M, Li JSZ, Sun Y, Ellisman MH, Ren B, Campbell PJ, Cleveland DW. Shoshani O, et al. Nature. 2021 Mar;591(7848):137-141. doi: 10.1038/s41586-020-03064-z. Epub 2020 Dec 23. Nature. 2021. PMID: 33361815 Free PMC article.

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