Recurrence of COVID-19 after recovery ? A case series in health care workers, France

doi:10.1016/j.micinf.2021.104803

Case Reports

. 2021 May-Jun;23(4-5):104803.

doi: 10.1016/j.micinf.2021.104803. Epub 2021 Mar 2.

Recurrence of COVID-19 after recovery ? A case series in health care workers, France

Souheil Zayet¹, Pierre-Yves Royer², Lynda Toko², Alix Pierron², Vincent Gendrin², Timothée Klopfenstein³

Affiliations

¹ Infectious Disease Department, Nord Franche-Comté Hospital, France. Electronic address: souhail.zayet@gmail.com.
² Infectious Disease Department, Nord Franche-Comté Hospital, France.
³ Infectious Disease Department, Nord Franche-Comté Hospital, France. Electronic address: timothee.klopfenstein@hnfc.fr.

PMID: 33667643
PMCID: PMC7923857
DOI: 10.1016/j.micinf.2021.104803

Case Reports

Recurrence of COVID-19 after recovery ? A case series in health care workers, France

Souheil Zayet et al. Microbes Infect. 2021 May-Jun.

. 2021 May-Jun;23(4-5):104803.

doi: 10.1016/j.micinf.2021.104803. Epub 2021 Mar 2.

Authors

Souheil Zayet¹, Pierre-Yves Royer², Lynda Toko², Alix Pierron², Vincent Gendrin², Timothée Klopfenstein³

Affiliations

¹ Infectious Disease Department, Nord Franche-Comté Hospital, France. Electronic address: souhail.zayet@gmail.com.
² Infectious Disease Department, Nord Franche-Comté Hospital, France.
³ Infectious Disease Department, Nord Franche-Comté Hospital, France. Electronic address: timothee.klopfenstein@hnfc.fr.

PMID: 33667643
PMCID: PMC7923857
DOI: 10.1016/j.micinf.2021.104803

Abstract

We describe 3 cases of coronavirus disease 2019 in health care workers in France involving presumed clinical and microbiological recurrence after recovery. All patients were immunocompetent with clinical mild form. These cases highlight the possibility of coronavirus disease-recurrence.

Keywords: COVID-19; Health care worker; Recovery; Recurrence; SARS-CoV-2.

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Figures

**Fig. 1**
Timeline in COVID-19 patients with recurrent infection after recovery. Abbrevations: HCW: health care workers; W: week.

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COVEVOL: Natural Evolution at 6 Months of COVID-19.
Messin L, Puyraveau M, Benabdallah Y, Lepiller Q, Gendrin V, Zayet S, Klopfenstein T, Toko L, Pierron A, Royer PY. Messin L, et al. Viruses. 2021 Oct 25;13(11):2151. doi: 10.3390/v13112151. Viruses. 2021. PMID: 34834958 Free PMC article.
Post-COVID-19 Syndrome: Nine Months after SARS-CoV-2 Infection in a Cohort of 354 Patients: Data from the First Wave of COVID-19 in Nord Franche-Comté Hospital, France.
Zayet S, Zahra H, Royer PY, Tipirdamaz C, Mercier J, Gendrin V, Lepiller Q, Marty-Quinternet S, Osman M, Belfeki N, Toko L, Garnier P, Pierron A, Plantin J, Messin L, Villemain M, Bouiller K, Klopfenstein T. Zayet S, et al. Microorganisms. 2021 Aug 12;9(8):1719. doi: 10.3390/microorganisms9081719. Microorganisms. 2021. PMID: 34442798 Free PMC article.
Third of patients have gustatory dysfunction 9 months after SARS-CoV-2 infection: the ANOSVID study.
Klopfenstein T, Tipirdamaz C, Gendrin V, Osman M, Mercier J, Bouvier E, Bouiller K, Lepiller Q, Toko L, Pierron A, Royer PY, Garnier P, Kadiane-Oussou NJ, Chirouze C, Zayet S. Klopfenstein T, et al. Int J Infect Dis. 2022 Jun;119:114-116. doi: 10.1016/j.ijid.2022.03.053. Epub 2022 Mar 30. Int J Infect Dis. 2022. PMID: 35364286 Free PMC article. No abstract available.
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Koupaei M, Mohamadi MH, Yashmi I, Shahabi AH, Shabani AH, Heidary M, Khoshnood S. Koupaei M, et al. J Clin Lab Anal. 2022 May;36(5):e24402. doi: 10.1002/jcla.24402. Epub 2022 Apr 8. J Clin Lab Anal. 2022. PMID: 35396748 Free PMC article.
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Batra K, Sharma M, Dai CL, Khubchandani J. Batra K, et al. Vaccines (Basel). 2022 May 11;10(5):758. doi: 10.3390/vaccines10050758. Vaccines (Basel). 2022. PMID: 35632514 Free PMC article.

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References

1. Sahu A.K., Amrithanand V.T., Mathew R., Aggarwal P., Nayer J., Bhoi S. COVID-19 in health care workers - a systematic review and meta-analysis. Am J Emerg Med. 2020;38(9):1727–1731. - PMC - PubMed
1. Kadiane-Oussou N.J., Klopfenstein T., Royer P.-Y., Toko L., Gendrin V., Zayet S. COVID-19: comparative clinical features and outcome in 114 patients with or without pneumonia (Nord Franche-Comte Hospital, France) Microb Infect. 2020 Oct 10;22(10):622–625. - PMC - PubMed
1. Gousseff M., Penot P., Gallay L., Batisse D., Benech N., Bouiller K. Clinical recurrences of COVID-19 symptoms after recovery: viral relapse, reinfection or inflammatory rebound? J Infect. 2020 Nov;81(5):816–846. - PMC - PubMed
1. Dao T.L., Hoang V.T., Gautret P. Recurrence of SARS-CoV-2 viral RNA in recovered COVID-19 patients: a narrative review. Eur J Clin Microbiol Infect Dis Off Publ Eur Soc Clin Microbiol. 2020 Oct 28;40(1):13–25. - PMC - PubMed
1. He F., Luo Q., Lei M., Fan L., Shao X., Hu K. Successful recovery of recurrence of positive SARS-CoV-2 RNA in COVID-19 patient with systemic lupus erythematosus: a case report and review. Clin Rheumatol. 2020 Sep;39(9):2803–2810. - PMC - PubMed

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[1] Sahu A.K., Amrithanand V.T., Mathew R., Aggarwal P., Nayer J., Bhoi S. COVID-19 in health care workers - a systematic review and meta-analysis. Am J Emerg Med. 2020;38(9):1727–1731. - PMC - PubMed

[2] Sahu A.K., Amrithanand V.T., Mathew R., Aggarwal P., Nayer J., Bhoi S. COVID-19 in health care workers - a systematic review and meta-analysis. Am J Emerg Med. 2020;38(9):1727–1731. - PMC - PubMed

[3] Kadiane-Oussou N.J., Klopfenstein T., Royer P.-Y., Toko L., Gendrin V., Zayet S. COVID-19: comparative clinical features and outcome in 114 patients with or without pneumonia (Nord Franche-Comte Hospital, France) Microb Infect. 2020 Oct 10;22(10):622–625. - PMC - PubMed

[4] Kadiane-Oussou N.J., Klopfenstein T., Royer P.-Y., Toko L., Gendrin V., Zayet S. COVID-19: comparative clinical features and outcome in 114 patients with or without pneumonia (Nord Franche-Comte Hospital, France) Microb Infect. 2020 Oct 10;22(10):622–625. - PMC - PubMed

[5] Gousseff M., Penot P., Gallay L., Batisse D., Benech N., Bouiller K. Clinical recurrences of COVID-19 symptoms after recovery: viral relapse, reinfection or inflammatory rebound? J Infect. 2020 Nov;81(5):816–846. - PMC - PubMed

[6] Gousseff M., Penot P., Gallay L., Batisse D., Benech N., Bouiller K. Clinical recurrences of COVID-19 symptoms after recovery: viral relapse, reinfection or inflammatory rebound? J Infect. 2020 Nov;81(5):816–846. - PMC - PubMed

[7] Dao T.L., Hoang V.T., Gautret P. Recurrence of SARS-CoV-2 viral RNA in recovered COVID-19 patients: a narrative review. Eur J Clin Microbiol Infect Dis Off Publ Eur Soc Clin Microbiol. 2020 Oct 28;40(1):13–25. - PMC - PubMed

[8] Dao T.L., Hoang V.T., Gautret P. Recurrence of SARS-CoV-2 viral RNA in recovered COVID-19 patients: a narrative review. Eur J Clin Microbiol Infect Dis Off Publ Eur Soc Clin Microbiol. 2020 Oct 28;40(1):13–25. - PMC - PubMed

[9] He F., Luo Q., Lei M., Fan L., Shao X., Hu K. Successful recovery of recurrence of positive SARS-CoV-2 RNA in COVID-19 patient with systemic lupus erythematosus: a case report and review. Clin Rheumatol. 2020 Sep;39(9):2803–2810. - PMC - PubMed

[10] He F., Luo Q., Lei M., Fan L., Shao X., Hu K. Successful recovery of recurrence of positive SARS-CoV-2 RNA in COVID-19 patient with systemic lupus erythematosus: a case report and review. Clin Rheumatol. 2020 Sep;39(9):2803–2810. - PMC - PubMed

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Recurrence of COVID-19 after recovery ? A case series in health care workers, France

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Recurrence of COVID-19 after recovery ? A case series in health care workers, France

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