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. 1988 May;81(5):1328-31.
doi: 10.1172/JCI113459.

Bowel necrosis induced by tumor necrosis factor in rats is mediated by platelet-activating factor

X M Sun  1 , W Hsueh
Affiliations

Bowel necrosis induced by tumor necrosis factor in rats is mediated by platelet-activating factor

X M Sun et al. J Clin Invest. 1988 May.

Abstract

We have developed a rat model of ischemic bowel necrosis associated with shock by injection of platelet-activating factor (PAF) or a combination of PAF and endotoxin. Recent investigations have shown that tumor necrosis factor (TNF) also induces shock and necrosis of the gastrointestinal tract. The morphological changes of TNF-induced bowel lesions are indistinguishable from those caused by PAF. The mechanism of TNF-induced bowel necrosis is unclear. In the present study, we have shown that (a) TNF caused PAF production in bowel tissue; (b) the effects of TNF and LPS on PAF production in the intestine are additive; (c) TNF and LPS are synergistic in inducing bowel necrosis; and (d) TNF-induced bowel necrosis is due to PAF release and can be prevented by pretreatment with PAF antagonists.

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