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Review
. 2021 Feb 28;11(3):412.
doi: 10.3390/diagnostics11030412.

Data Integration Reveals the Potential Biomarkers of Circulating MicroRNAs in Osteoarthritis

Thuan Duc Lao  1 , Thuy Ai Huyen Le  1
Affiliations
Review

Data Integration Reveals the Potential Biomarkers of Circulating MicroRNAs in Osteoarthritis

Thuan Duc Lao et al. Diagnostics (Basel). .

Abstract

The abnormal expression of circulating miRNAs (c-miRNAs) has become an emerging field in the development of miRNAs-based diagnostic and therapeutic tools for human diseases, including osteoarthritis (OA). OA is the most common form of arthritis leading to disability and a major socioeconomic burden. The abnormal expression of miRNAs plays important roles in the pathogenesis of OA. Unraveling the role of miRNAs in the pathogenesis of OA will throw light on the potential for the development of miRNAs-based diagnostic and therapeutic tools for OA. This article reviews and highlights recent advances in the study of miRNAs in OA, with specific demonstration of the functions of miRNA, especially c-miRNA, in OA pathogenesis as well as its potential implication in the treatment of OA. Based on a systematic literature search using online databases, we figured out the following main points: (1) the integrative systematic review of c-mRNAs and its target genes related to OA pathogenesis; (2) the potential use of c-miRNAs for OA diagnosis purposes as potential biomarkers; and (3) for therapeutic purposes, and we also highlight certain remedies that regulate microRNA expression based on its target genes.

Keywords: circulating miRNAs; miRNAs-based diagnosis; miRNAs-based therapeutic; osteoarthritis.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Schematic representation of miR-146 and its target genes related to pathogenesis of OA.
See this image and copyright information in PMC

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