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. 2021 Feb 28;9(3):508.
doi: 10.3390/microorganisms9030508.

CAPPRIC Study-Characterization of Community-Acquired Pneumonia in Spanish Adults Managed in Primary Care Settings

Jesús Molina  1 , Amelia González-Gamarra  2 , Leovigildo Ginel  3 , Mª Encarnación Peláez  4 , Juan Luis Juez  5 , Antonio Artuñedo  6 , Gonzalo Aldana  7 , Enriqueta Quesada  8 , Joan Josep Cabré  9 , Antonio Gómez  10 , Manuel Linares  11 , Maria Teresa Marín  12 , Pilar Yolanda Sanchez  13 , Leonor Núñez  14 , Jaime Gonzálvez  15 , Enrique Mascarós  16 , Javier López  17 , Agustina Cano  18 , José Herrero  19 , María Carmen Serra  20 , Enrique Cimas  21 , Marta Pedrol  22 , Juan Vicente Alfaro  23 , Federico Martinón-Torres  24 , Isabel Cifuentes  25 , Cristina Méndez  25 , Daniel Ocaña  26 , On Behalf Of The Cappric Study Group
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CAPPRIC Study-Characterization of Community-Acquired Pneumonia in Spanish Adults Managed in Primary Care Settings

Jesús Molina et al. Microorganisms. .

Abstract

The real burden of community-acquired pneumonia (CAP) in non-hospitalized patients is largely unknown. This is a 3-year prospective, observational study of ambulatory CAP in adults, conducted in 24 Spanish primary care centers between 2016-2019. Sociodemographic and clinical variables of patients with radiographically confirmed CAP were collected. Pneumococcal etiology was assessed using the Binax Now® test. Patients were followed up for 10 ± 3 days. A total of 456 CAP patients were included in the study. Mean age was 56.6 (±17.5) years, 53.5% were female, and 53.9% had ≥1 comorbidity. Average incidence of CAP was 1.2-3.5 cases per 1000 persons per year. Eighteen patients (3.9%) were classified as pneumococcal CAP. Cough was present in 88.1% of patients at diagnosis and fever in 70.8%. Increased pulmonary density (63.3%) and alveolar infiltrates with air bronchogram (16.6%) were the most common radiographic findings. After 14.6 ± 6.0 days (95% CI = 13.9-15.3), 65.4% of patients had recovered. Hospitalization rate was 2.8%. The most frequently prescribed antibiotics were quinolones (58.7%) and β-lactams (31.1%). In conclusion, one-third of CAP patients did not fully recover after two weeks of empiric antibiotic therapy and 2.8% required hospitalization, highlighting the significant burden associated with non-hospitalized CAP in Spain.

Keywords: CAP; ambulatory; community-acquired pneumonia; non-hospitalized; outpatient; pneumococcal CAP.

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Conflict of interest statement

J.M., A.G.-G., L.G., M.E.P., J.L.J., A.A., G.A., E.Q., J.J.C., A.G., M.L., M.T.M., P.Y.S., L.N., J.G., E.M., J.L., A.C., J.H., M.C.S., E.C., M.P., J.V.A., F.M.-T. and D.O. reports grants to their institutions from Pfizer S.L.U., Madrid, Spain for this study; J.M. has received personal fees from AstraZeneca, GSK, Chiesi and Novartis, during the conduct of the study; F.M.-T. has received honoraria from GSK, Pfizer S.L.U., Sanofi Pasteur, MSD, Seqirus, and Janssen for taking part in advisory boards and expert meetings, and for acting as speaker in congresses outside the scope of the submitted work. FM-T has also acted as principal investigator in RCTs of the above-mentioned companies, and Ablynx, Regeneron, Roche, Abbott, Novavax, and MedImmune, with honoraria paid to his institution; D.O. reports personal fees from Pfizer S.L.U., during the conduct of the study; personal fees from Sanofi Pasteur and Seqirus and non-financial support from Sanofi Pasteur and from MSD, outside the submitted work; I.C. and C.M. are employees of Pfizer S.L.U., Madrid, Spain.

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