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. 1988 Mar;24(3):343-9.
doi: 10.1002/jmv.1890240311.

Significance of maternal and infant serum antibodies to hepatitis B core antigen in hepatitis B virus infection of infancy

S K Panda  1 , M K Bhan, D K Guha, A Gupta, R Datta, A J Zuckerman, N C Nayak
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Significance of maternal and infant serum antibodies to hepatitis B core antigen in hepatitis B virus infection of infancy

S K Panda et al. J Med Virol. 1988 Mar.

Abstract

The significance of IgM and IgG class antibodies to hepatitis B virus (HBV) core component (anti-HBc) was investigated in a study of maternal-fetal HBV transmission. An IgM anti-HBc response was lacking in the majority (49/53) of HBV-infected infants. This antibody thus cannot be used as an indicator of transplacental infection. However, most infants who became HBsAg positive during the first 6 months of life acquire infection in the perinatal period rather than transplacentally. Passively transferred maternal IgG anti-HBc in the infant and additional IgM anti-HBc positively in the carrier mother have no modulating influence on HBV infection of infants born to HBV carrier women.

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