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Review
. 2021 Feb 17;11(2):300.
doi: 10.3390/biom11020300.

Challenges and Perspective in Integrated Multi-Omics in Gut Microbiota Studies

Eric Banan-Mwine Daliri  1 , Fred Kwame Ofosu  1 , Ramachandran Chelliah  1 , Byong H Lee  2 , Deog-Hwan Oh  1
Affiliations
Review

Challenges and Perspective in Integrated Multi-Omics in Gut Microbiota Studies

Eric Banan-Mwine Daliri et al. Biomolecules. .

Abstract

The advent of omic technology has made it possible to identify viable but unculturable micro-organisms in the gut. Therefore, application of multi-omic technologies in gut microbiome studies has become invaluable for unveiling a comprehensive interaction between these commensals in health and disease. Meanwhile, despite the successful identification of many microbial and host-microbial cometabolites that have been reported so far, it remains difficult to clearly identify the origin and function of some proteins and metabolites that are detected in gut samples. However, the application of single omic techniques for studying the gut microbiome comes with its own challenges which may be overcome if a number of different omics techniques are combined. In this review, we discuss our current knowledge about multi-omic techniques, their challenges and future perspective in this field of gut microbiome studies.

Keywords: Microbiome; biomarkers; metagenomics; metatranscriptomics; multi-omics.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Omic technologies and the information they provide in gut-microbiome research.
See this image and copyright information in PMC

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