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. 2021 Feb 22;13(4):912.
doi: 10.3390/cancers13040912.

Quality Assurance in Modern Gynecological HDR-Brachytherapy (Interventional Radiotherapy): Clinical Considerations and Comments

Tamer Soror  1   2 , Frank-André Siebert  3 , Valentina Lancellotta  4 , Elisa Placidi  4 , Bruno Fionda  4 , Luca Tagliaferri  4 , György Kovács  5
Affiliations

Quality Assurance in Modern Gynecological HDR-Brachytherapy (Interventional Radiotherapy): Clinical Considerations and Comments

Tamer Soror et al. Cancers (Basel). .

Abstract

The use of brachytherapy (interventional radiotherapy) in the treatment of gynecological cancers is a crucial element in both definitive and adjuvant settings. The recent developments in high-dose rate remote afterloaders, modern applicators, treatment-planning software, image guidance, and dose monitoring systems have led to improvement in the local control rates and in some cases improved the survival rates. The development of these highly advanced and complicated treatment modalities has been accompanied by challenges, which have made the existence of quality assurance protocols a must to ensure the integrity of the treatment process. Quality assurance aims at standardizing the technical and clinical procedures involved in the treatment of patients, which could eventually decrease the source of uncertainties whether technical (source/equipment related) or clinical. This commentary review sheds light (from a clinical point of view) on some potential sources of uncertainties associated with the use of modern brachytherapy in the treatment of gynecological cancers.

Keywords: brachytherapy; gynecological cancers; interventional radiotherapy; quality assurance.

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Georg D., Kirisits C., Hillbrand M., Dimopoulos J., Pötter R. Image-Guided Radiotherapy for Cervix Cancer: High-Tech External Beam Therapy Versus High-Tech Brachytherapy. Int. J. Radiat. Oncol. Biol. Phys. 2008;71:1272–1278. doi: 10.1016/j.ijrobp.2008.03.032. - DOI - PubMed
    1. Sturdza A., Pötter R., Fokdal L.U., Haie-Meder C., Tan L.T., Mazeron R., Petric P., Šegedin B., Jurgenliemk-Schulz I.M., Nomden C., et al. Image guided brachytherapy in locally advanced cervical cancer: Improved pelvic control and survival in RetroEMBRACE, a multicenter cohort study. Radiother. Oncol. 2016;120:428–433. doi: 10.1016/j.radonc.2016.03.011. - DOI - PubMed
    1. Lanciano R.M., Won M., Coia L.R., Hanks G.E. Pretreatment and treatment factors associated with improved outcome in squamous cell carcinoma of the uterine cervix: A final report of the 1973 and 1978 patterns of care studies. Int. J. Radiat. Oncol. Biol. Phys. 1991;20:667–676. doi: 10.1016/0360-3016(91)90007-Q. - DOI - PubMed
    1. Lanciano R.M., Martz K., Coia L.R., Hanks G.E. Tumor and treatment factors improving outcome in stage III-B cervix cancer. Int. J. Radiat. Oncol. Biol. Phys. 1991;20:95–100. doi: 10.1016/0360-3016(91)90143-R. - DOI - PubMed
    1. Montana G.S., Martz K.L., Hanks G.E. Patterns and sites of failure in cervix cancer treated in the U.S.A. in 1978. Int. J. Radiat. Oncol. Biol. Phys. 1991;20:87–93. doi: 10.1016/0360-3016(91)90142-Q. - DOI - PubMed

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