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. 1988 Jan;235(3):168-70.
doi: 10.1007/BF00314310.

Primidone and essential tremor

S Seyfert  1 , A Honé, G Holl
Affiliations

Primidone and essential tremor

S Seyfert et al. J Neurol. 1988 Jan.

Abstract

To clarify whether primidone itself, and not only its metabolite phenobarbitone, suppresses essential tremor, the effect of a high single dose of primidone was tested. Of 11 patients, 8 showed a reduction of their tremor by 54%-69% for up to 28 h. The serum concentration of primidone was as expected, whereas those of the metabolites phenyl-ethyl-malonamide and phenobarbitone were very low. The tremor suppression can thus be considered to be an effect of primidone. Three of the 11 patients did not show a reduction of tremor.

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