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. 2021 Feb 22;13(2):169.
doi: 10.3390/toxins13020169.

Use of AbobotulinumtoxinA for Cosmetic Treatments in the Neck, and Middle and Lower Areas of the Face: A Systematic Review

Hassan Galadari  1 , Ibrahim Galadari  1 , Riekie Smit  2 , Inna Prygova  3 , Alessio Redaelli  4
Affiliations

Use of AbobotulinumtoxinA for Cosmetic Treatments in the Neck, and Middle and Lower Areas of the Face: A Systematic Review

Hassan Galadari et al. Toxins (Basel). .

Abstract

AbobotulinumtoxinA (aboBoNT-A) has been used for various cosmetic purposes, including minimization of moderate to severe lines, or other cosmetic indications, in the face and neck. We carried out a systematic review to identify all relevant evidence on the treatment approaches and outcomes of aboBoNT-A as a cosmetic treatment of the middle and lower areas of the face, and the neck. Embase, MEDLINE, Cochrane Library, congress proceedings and review bibliographies were searched for relevant studies. Identified articles were screened against pre-specified eligibility criteria. Of 560 unique articles identified, 10 were included for data extraction (three observational studies, 1 randomized controlled trial [with two articles] and five non-randomized trials). The articles provided data on gummy/asymmetric smile (2), marionette lines (5), masseter muscle volume (2), nasal wrinkles (2), perioral wrinkles (3) and the platysma muscle (4). All articles reporting on efficacy of aboBoNT-A demonstrated positive results, including reduction of wrinkles (5), reduction of masseter muscle (2) and degree of gummy smile (1) compared with before treatment. No serious adverse events were reported and patient satisfaction was high. In conclusion, positive findings support further research of aboBoNT-A for the middle and lower areas of the face, and in the neck, which are largely unapproved indications.

Keywords: abobotulinumtoxinA; botulinum toxin; lower face; marionette lines; masseter; middle face; neck; perioral area; platysma.

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Conflict of interest statement

Hassan Galadari and Ibrahim Galadari have no conflicts of interest to disclose; Inna Prygova is an Ipsen employee; Alessio Redaelli reports personal fees from Ipsen during the conduct of the study and personal fees from Ipsen and Fillmed Laboratories and other financial activities from OEO Florence Editor outside of the submitted work; Riekie Smit reports honoraria for conference presentations or workshops received from Ipsen, Fillmed Laboratories, Hansbiomed and Inova Pharmaceuticals. The sponsor, Ipsen, was not involved in the study design, data collection, data analysis, manuscript preparation or publication decisions.

Figures

Figure 1
Figure 1
Preferred Reporting Items for Systematic Reviews and Meta-Analyses flow diagram. References were excluded at full-text review stage owing to no relevant data as follows: (1) duplicates, (2) editorial/commentary, (3) population not of interest, (4) intervention not of interest (not aboBoNT-A), (5) outcomes not of interest, (6) study design (non-randomized controlled trial/modeling study/case series or studies), (7) study not in English, (8) in vitro/animal study and (9) website source. Narrative reviews were included for first screening so that any relevant cited studies could be identified and were excluded at full-text review.
Figure 2
Figure 2
AbobotulinumtoxinA dilutions used for different indications.
Figure 3
Figure 3
Patient satisfaction with abobotulinumtoxinA (aboBoNT-A) treatment. References: Awaida et al. [26]; Hexsel et al. [29]; Mazzuco and Hexsel [22]; Kim et al. [25]; Jabbour et al. [24].
See this image and copyright information in PMC

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