Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Feb 23;57(2):189.
doi: 10.3390/medicina57020189.

Focused Review: Potential Rare and Atypical Symptoms as Indicator for Targeted COVID-19 Screening

Swee Li Ng  1 , Yong Sze Ong  1   2 , Kooi Yeong Khaw  1   3 , Siew Phooi Teh  1   4 , Ching Siang Tan  5 , Long Chiau Ming  6 , Kok-Gan Chan  7   8 , Learn-Han Lee  9 , Bey-Hing Goh  1   4
Affiliations
Review

Focused Review: Potential Rare and Atypical Symptoms as Indicator for Targeted COVID-19 Screening

Swee Li Ng et al. Medicina (Kaunas). .

Abstract

The global pandemic of the coronavirus disease 2019 is a known consequence of infection of severe respiratory syndrome coronavirus-2 (SARS-CoV-2). It has affected nations worldwide with soaring number of cases daily. Symptoms such as fever, cough, and shortness of breath, diarrhea, nausea and vomiting are commonly presented in COVID-19 patients. This focused review aims to discuss these uncommon and atypical COVID-19 symptoms that may be presented which might affect neurological, cardiovascular, cutaneous and ocular systems and their possible mode of actions. Nonetheless, there are some cases of reported uncommon or atypical symptoms which may warrant healthcare professionals to be aware of, especially when in contact with patients. The knowledge and information concerning these symptoms might be able to provide additional cues for healthcare professional by subjecting patients to COVID-19 screening. Meanwhile, it might be able to further enhance the alertness and additional precautions being taken by healthcare personnel, which eventually lead to reduced risk of infections.

Keywords: COVID-19; detection; infection; screening; symptoms.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Goh H.P., Mahari W.I., Ahad N.I., Chaw L.L., Kifli N., Goh B.-H., Yeoh S.F., Goh K.W., Ming L.C. Risk factors affecting COVID-19 case fatality rate: A quantitative analysis of top 50 affected countries. Prog. Microbes Mol. Biol. 2020;3:a0000171. doi: 10.36877/pmmb.a0000171. - DOI
    1. World Health Organization WHO Coronavirus Disease (COVID-19) Dashboard. [(accessed on 9 January 2021)]; Available online: https://covid19.who.int/
    1. Gencer S., Lacy M., Atzler D., van der Vorst E.P.C., Doring Y., Weber C. Immunoinflammatory, Thrombohaemostatic, and Cardiovascular Mechanisms in COVID-19. Thromb. Haemost. 2020;120:1629–1641. doi: 10.1055/s-0040-1718735. - DOI - PMC - PubMed
    1. Tan C.S., Yeoh S.F., Long C.M. COVID-19: Critical Role of Angiotensin 1–7 in ACE2 Modulation. Ann. Acad. Med. 2020;49:398–400. - PubMed
    1. National Health Commission & State Administration of Traditional Chinese Medicine . In: Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia. 7th ed. Wei P.-F., editor. National Health Commission of the People’s Republic of China; Beijing, China: 2020. p. 17. Trial Version.