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Review
. 2021 Feb 20;7(1):16.
doi: 10.3390/ncrna7010016.

The Role of LncRNAs in Translation

Didem Karakas  1 , Bulent Ozpolat  2
Affiliations
Review

The Role of LncRNAs in Translation

Didem Karakas et al. Noncoding RNA. .

Abstract

Long non-coding RNAs (lncRNAs), a group of non-protein coding RNAs with lengths of more than 200 nucleotides, exert their effects by binding to DNA, mRNA, microRNA, and proteins and regulate gene expression at the transcriptional, post-transcriptional, translational, and post-translational levels. Depending on cellular location, lncRNAs are involved in a wide range of cellular functions, including chromatin modification, transcriptional activation, transcriptional interference, scaffolding and regulation of translational machinery. This review highlights recent studies on lncRNAs in the regulation of protein translation by modulating the translational factors (i.e, eIF4E, eIF4G, eIF4A, 4E-BP1, eEF5A) and signaling pathways involved in this process as wells as their potential roles as tumor suppressors or tumor promoters.

Keywords: cancer; long non-coding RNAs; ncRNAs; non-coding RNAs; translation.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Some lncRNAs are identified to be involved in aggressive characteristics of some common types of cancers [61,102,103,104,105,106,107,108,109,110,111,112,113,114,115,116,117,118,119,120,121,122,123,124,125,126,127,128,129,130,131,132,133,134,135,136,137,138,139,140,141,142,143,144,145,146,147].
Figure 2
Figure 2
The mechanisms of action of lncRNAs on the regulation of cancer-related protein translation [31,34,35,38,64,67,68,82,84,85,86,87,148,151,153].
See this image and copyright information in PMC

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