Prepulse Inhibition in Cocaine Addiction and Dual Pathologies
- PMID: 33672693
- PMCID: PMC7924364
- DOI: 10.3390/brainsci11020269
Prepulse Inhibition in Cocaine Addiction and Dual Pathologies
Abstract
Cocaine addiction is frequently associated with different psychiatric disorders, especially schizophrenia and antisocial personality disorder. A small number of studies have used prepulse inhibition (PPI) as a discriminating factor between these disorders. This work evaluated PPI and the phenotype of patients with cocaine-related disorder (CRD) who presented a dual diagnosis of schizophrenia or antisocial personality disorder. A total of 74 men aged 18-60 years were recruited for this research. The sample was divided into four groups: CRD (n = 14), CRD and schizophrenia (n = 21), CRD and antisocial personality disorder (n = 16), and a control group (n = 23). We evaluated the PPI and other possible vulnerability factors in these patients by using different assessment scales. PPI was higher in the CRD group at 30 ms (F(3, 64) = 2.972, p = 0.038). Three discriminant functions were obtained which allowed us to use the overall Hare Psychopathy Checklist Revised score, reward sensitivity, and PPI at 30 ms to predict inclusion of these patients in the different groups with a success rate of 79.7% (42.9% for CRD, 76.2% for CRD and schizophrenia, 100% for CRD and antisocial personality disorder, and 91.3% in the control group). Despite the differences we observed in PPI, this factor is of little use for discriminating between the different diagnostic groups and it acts more as a non-specific endophenotype in certain mental disorders, such as in patients with a dual diagnosis.
Keywords: antisocial personality disorder; cocaine-related disorder; dual diagnosis; prepulse inhibition; psychopathy; schizophrenia.
Conflict of interest statement
The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.
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References
-
- EU Drug Markets Report 2019. Publications Office of the European Union; Luxembourg: 2019. European Monitoring Centre for Drugs and Drug Addiction and Europol.
-
- Barnaby L., Gibson R.C. Factors affecting completion of a 28-day inpatient substance abuse treatment programme at the University Hospital of the West Indies. West. Indian Med. J. 2008;57:364–368. - PubMed
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