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. 2021 Feb 14;13(2):620.
doi: 10.3390/nu13020620.

Asprosin-A Fasting-Induced, Glucogenic, and Orexigenic Adipokine as a New Promising Player. Will It Be a New Factor in the Treatment of Obesity, Diabetes, or Infertility? A Review of the Literature

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Asprosin-A Fasting-Induced, Glucogenic, and Orexigenic Adipokine as a New Promising Player. Will It Be a New Factor in the Treatment of Obesity, Diabetes, or Infertility? A Review of the Literature

Agnieszka Irena Mazur-Bialy. Nutrients. .

Abstract

Asprosin is a recently discovered protein released during fasting conditions mainly by adipocytes from white adipose tissue. As a glucogenic peptide, it stimulates the release of glucose from hepatic cells by binding to the OLFR734 receptor and leading to the activation of the G protein-cAMP-PKA pathway. As it crosses the blood-brain barrier, it also acts as an orexigenic peptide that stimulates food intake through activation of AgRP neurons in the hypothalamus; thus, asprosin participates in maintaining the body's energy homeostasis. Moreover, studies have shown that asprosin levels are pathologically elevated in obesity and related diseases. However, the administration of anti-asprosin antibodies can both normalize its concentration and reduce food intake in obese mice, which makes it an interesting factor to combat obesity and related diseases. Current research also draws attention to the relationship between asprosin and fertility, especially in men. Asprosin improves age- and obesity-related decrease in fertility potential by improving sperm motility. It should also be mentioned that plasma asprosin levels can be differentially modulated by physical activity; intense anaerobic exercise increases asprosin level, while aerobic exercise decreases it. However, further research is necessary to confirm the exact mechanisms of asprosin activity and its potential as a therapeutic target.

Keywords: PCOS; appetite; asprosin; exercise; fertility; insulin resistance; obesity.

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Figure 1
Figure 1
Diagram PRISMA—presents the different phases of the systematic review carried out.
Figure 2
Figure 2
Mechanisms of asprosin action in fasting and obese state.

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References

    1. Fantuzzi G. Adipose tissue, adipokines, and inflammation. J. Allergy Clin. Immunol. 2005;115:911–919. doi: 10.1016/j.jaci.2005.02.023. - DOI - PubMed
    1. Trayhurn P., Wood I.S. Adipokines: Inflammation and the pleiotropic role of white adipose tissue. Br. J. Nutr. 2004;92:347–355. doi: 10.1079/BJN20041213. - DOI - PubMed
    1. Fasshauer M., Blüher M. Adipokines in health and disease. Trends Pharmacol. Sci. 2015;36:461–470. doi: 10.1016/j.tips.2015.04.014. - DOI - PubMed
    1. Korta P., Pocheć E., Mazur-Biały A. Irisin as a Multifunctional Protein: Implications for Health and Certain Diseases. Medicina. 2019;55:485. doi: 10.3390/medicina55080485. - DOI - PMC - PubMed
    1. Münzberg H., Morrison C.D. Structure, production and signaling of leptin. Metabolism. 2015;64:13–23. doi: 10.1016/j.metabol.2014.09.010. - DOI - PMC - PubMed

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