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Review
. 2021 Feb 12;22(4):1844.
doi: 10.3390/ijms22041844.

Trajectory Shifts in Interdisciplinary Research of the Aryl Hydrocarbon Receptor-A Personal Perspective on Thymus and Skin

Charlotte Esser  1
Affiliations
Review

Trajectory Shifts in Interdisciplinary Research of the Aryl Hydrocarbon Receptor-A Personal Perspective on Thymus and Skin

Charlotte Esser. Int J Mol Sci. .

Abstract

Identifying historical trajectories is a useful exercise in research, as it helps clarify important, perhaps even "paradigmatic", shifts in thinking and moving forward in science. In this review, the development of research regarding the role of the transcription factor "aryl hydrocarbon receptor" (AHR) as a mediator of the toxicity of environmental pollution towards a link between the environment and a healthy adaptive response of the immune system and the skin is discussed. From this fascinating development, the opportunities for targeting the AHR in the therapy of many diseases become clear.

Keywords: 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD); aryl hydrocarbon receptor (AHR); immune system; skin; therapeutic target; thymus.

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Conflict of interest statement

I declare that I have no conflict of interest.

Figures

Figure 1
Figure 1
Overview of Major Parameters Influencing AHR signaling outcomes. Please see references in Text and Table 1 for details.
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