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. 2021 Feb 27;19(3):130.
doi: 10.3390/md19030130.

Cembranoids from Octocoral Lobophytum crassum (von Marenzeller, 1886)

Yao-Tsung Yeh  1   2 , Sung-Chun Lin  3 , Gene-Hsiang Lee  4 , Zhi-Hong Wen  5   6 , Tsong-Long Hwang  7   8   9   10 , Yu-Jen Wu  11 , Jih-Jung Chen  12 , Lee-Shing Fang  5   13   14 , Mei-Kang Yuan  15   16 , Ping-Jyun Sung  1   2   5   17   18
Affiliations

Cembranoids from Octocoral Lobophytum crassum (von Marenzeller, 1886)

Yao-Tsung Yeh et al. Mar Drugs. .

Abstract

Two cembranoids, including a new compound, lobocrassin I (1), as well as a known analogue, lobohedleolide (2), were obtained by solvent extraction from octocoral Lobophytum crassum. This study employed a spectroscopic approach to establish the structures of these two cembranoids, and utilized single-crystal X-ray diffraction analysis to determine their absolute configurations. The results of biological activity assays demonstrated that cembranoid 2 exhibited bioactivity against the protein expressions of inducible nitric oxide synthase (iNOS) lipopolysaccharide (LPS)-treated RAW 264.7 mouse macrophage cells.

Keywords: Lobophytum crassum; X-ray; anti-inflammation; cembranoid; iNOS; lobocrassin; lobohedleolide.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Structures of lobocrassin I (1) and lobohedleolide (2).
Figure 2
Figure 2
Major COSY (formula image) and HMBC (formula image) correlations of 1.
Figure 3
Figure 3
Major protons with NOESY (formula image) correlations of 1.
Figure 4
Figure 4
ORTEP plot revealing the absolute configuration of 1.
Figure 5
Figure 5
ORTEP plot revealing the absolute configuration of 2.
See this image and copyright information in PMC

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