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Review
. 2021 Feb 27;9(3):199.
doi: 10.3390/vaccines9030199.

Enterovirus A71 Vaccines

Mei-Ling Li  1 , Shin-Ru Shih  2   3   4   5 , Blanton S Tolbert  6 , Gary Brewer  1
Affiliations
Review

Enterovirus A71 Vaccines

Mei-Ling Li et al. Vaccines (Basel). .

Abstract

Enterovirus A71 (EV-A71) is a major causative agent of hand, foot, and mouth disease (HFMD) and herpangina. Moreover, EV-A71 infection can lead to neurological complications and death. Vaccination is the most efficient way to control virus infection. There are currently three inactivated, whole EV-A71 vaccines licensed by the China NMPA (National Medical Products Administration). Several other types of vaccines, such as virus-like particles and recombinant VP1 (capsid protein), are also under development. In this review, we discuss recent advances in the development of EV-A71 vaccines.

Keywords: Enterovirus A71; Sinovac; foot and mouth disease (HFMD); hand; vaccine.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Structure of the EV-A71 genome and the encoded viral proteins. The single open reading frame (ORF) is flanked by a highly structured 5′UTR and 3′UTR followed by a poly (A) tail. The 5′ end of the viral genome is covalently bound to the viral VPg protein. The ORF is divided into three regions. P1 encodes four structural (capsid) proteins, VP1–4. P2 and P3 encode seven nonstructural proteins, 2 A to 2 C and 3 A to 3 D, respectively [11].
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