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Review
. 2021 Feb 27;13(5):998.
doi: 10.3390/cancers13050998.

History of Extensive Disease Small Cell Lung Cancer Treatment: Time to Raise the Bar? A Review of the Literature

Chiara Lazzari  1 , Aurora Mirabile  1 , Alessandra Bulotta  1 , Maria Grazia Viganó  1 , Francesca Rita Ogliari  1 , Stefania Ippati  1 , Italo DellOca  2 , Mariacarmela Santarpia  3 , Vincenza Lorusso  1 , Martin Reck  4 , Vanesa Gregorc  1
Affiliations
Review

History of Extensive Disease Small Cell Lung Cancer Treatment: Time to Raise the Bar? A Review of the Literature

Chiara Lazzari et al. Cancers (Basel). .

Abstract

Several trials have tried for decades to improve the outcome of extensive disease small cell lung cancer (ED-SCLC) through attempts to modify the standard treatments. Nevertheless, platinum/etoposide combination and topotecan have remained respectively the first and the second line standard treatments for the last 40 years. With the advent of immunotherapy, this scenario has finally changed. Our review aims to provide an overview of the primary studies on the actual therapeutic strategies available for ED-SCLC patients, and to highlight emerging evidence supporting the use of immunotherapy in SCLC patients.

Keywords: Immunotherapy; chemotherapy; extensive disease; small cell lung cancer.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
(A) Immunotherapy treatment strategies currently approved or tested in patients with ED-SCLC. (B) Approved chemotherapy treatments for patients with ED-SCLC. (C) Potentially targetable and identified molecular pathways in ED-SCLC.
See this image and copyright information in PMC

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