Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Mar 5;22(1):79.
doi: 10.1186/s12882-021-02278-1.

Renal transplantation outcomes in obese patients: a French cohort-based study

Y Foucher  1   2 , M Lorent  3   4   5 , L Albano  6 , S Roux  3 , V Pernin  7 , M Le Quintrec  7 , C Legendre  8 , F Buron  9 , E Morelon  9 , S Girerd  10 , M Ladrière  10 , D Glotz  11 , C Lefaucher  11 , C Kerleau  4   5 , J Dantal  4   5   12 , J Branchereau  4   5   12 , M Giral  4   5   12 ; DIVAT consortium
Collaborators, Affiliations

Renal transplantation outcomes in obese patients: a French cohort-based study

Y Foucher et al. BMC Nephrol. .

Abstract

Background: Whilst there are a number of publications comparing the relationship between body mass index (BMI) of kidney transplant recipients and graft/patient survival, no study has assessed this for a French patient cohort.

Methods: In this study, cause-specific Cox models were used to study patient and graft survival and several other time-to-event measures. Logistic regressions were performed to study surgical complications at 30 days post-transplantation as well as delayed graft function.

Results: Among the 4691 included patients, 747 patients were considered obese with a BMI level greater than 30 kg/m2. We observed a higher mortality for obese recipients (HR = 1.37, p = 0.0086) and higher risks of serious bacterial infections (HR = 1.24, p = 0.0006) and cardiac complications (HR = 1.45, p < 0.0001). We observed a trend towards death censored graft survival (HR = 1.22, p = 0.0666) and no significant increased risk of early surgical complications.

Conclusions: We showed that obesity increased the risk of death and serious bacterial infections and cardiac complications in obese French kidney transplant recipients. Further epidemiologic studies aiming to compare obese recipients versus obese candidates remaining on dialysis are needed to improve the guidelines for obese patient transplant allocation.

Keywords: Cohort study; Kidney transplantation; Obesity; Post-transplant outcomes.

PubMed Disclaimer

Conflict of interest statement

The authors of this manuscript have no conflict of interest to disclose for this study.

Figures

Fig. 1
Fig. 1
Patient and graft survival curves according to obesity status
Fig. 2
Fig. 2
Summary of adjusted relative effects of obese versus non-obese recipients
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Obesity and overweight. https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight. Accessed 26 Dec 2019.
    1. NCD Risk Factor Collaboration (NCD-RisC) Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19·2 million participants. Lancet Lond Engl. 2016;387:1377–1396. doi: 10.1016/S0140-6736(16)30054-X. - DOI - PMC - PubMed
    1. Obermayr RP, Temml C, Knechtelsdorfer M, Gutjahr G, Kletzmayr J, Heiss S, et al. Predictors of new-onset decline in kidney function in a general middle-european population. Nephrol Dial Transplant Off Publ Eur Dial Transpl Assoc - Eur Ren Assoc. 2008;23:1265–1273. - PubMed
    1. Kramer HJ, Saranathan A, Luke A, Durazo-Arvizu RA, Guichan C, Hou S, et al. Increasing body mass index and obesity in the incident ESRD population. J Am Soc Nephrol JASN. 2006;17:1453–1459. doi: 10.1681/ASN.2005111241. - DOI - PubMed
    1. Vashistha T, Mehrotra R, Park J, Streja E, Dukkipati R, Nissenson AR, et al. Effect of age and dialysis vintage on obesity paradox in long-term hemodialysis patients. Am J Kidney Dis Off J Natl Kidney Found. 2014;63:612–622. doi: 10.1053/j.ajkd.2013.07.021. - DOI - PMC - PubMed

Publication types