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. 2021 Mar 5;22(1):79.
doi: 10.1186/s12882-021-02278-1.

Renal transplantation outcomes in obese patients: a French cohort-based study

Y Foucher  1   2 , M Lorent  3   4   5 , L Albano  6 , S Roux  3 , V Pernin  7 , M Le Quintrec  7 , C Legendre  8 , F Buron  9 , E Morelon  9 , S Girerd  10 , M Ladrière  10 , D Glotz  11 , C Lefaucher  11 , C Kerleau  4   5 , J Dantal  4   5   12 , J Branchereau  4   5   12 , M Giral  4   5   12 ; DIVAT consortium
Collaborators, Affiliations

Renal transplantation outcomes in obese patients: a French cohort-based study

Y Foucher et al. BMC Nephrol. .

Abstract

Background: Whilst there are a number of publications comparing the relationship between body mass index (BMI) of kidney transplant recipients and graft/patient survival, no study has assessed this for a French patient cohort.

Methods: In this study, cause-specific Cox models were used to study patient and graft survival and several other time-to-event measures. Logistic regressions were performed to study surgical complications at 30 days post-transplantation as well as delayed graft function.

Results: Among the 4691 included patients, 747 patients were considered obese with a BMI level greater than 30 kg/m2. We observed a higher mortality for obese recipients (HR = 1.37, p = 0.0086) and higher risks of serious bacterial infections (HR = 1.24, p = 0.0006) and cardiac complications (HR = 1.45, p < 0.0001). We observed a trend towards death censored graft survival (HR = 1.22, p = 0.0666) and no significant increased risk of early surgical complications.

Conclusions: We showed that obesity increased the risk of death and serious bacterial infections and cardiac complications in obese French kidney transplant recipients. Further epidemiologic studies aiming to compare obese recipients versus obese candidates remaining on dialysis are needed to improve the guidelines for obese patient transplant allocation.

Keywords: Cohort study; Kidney transplantation; Obesity; Post-transplant outcomes.

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Conflict of interest statement

The authors of this manuscript have no conflict of interest to disclose for this study.

Figures

Fig. 1
Fig. 1
Patient and graft survival curves according to obesity status
Fig. 2
Fig. 2
Summary of adjusted relative effects of obese versus non-obese recipients
See this image and copyright information in PMC

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