Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2021 Mar;96(3):601-618.
doi: 10.1016/j.mayocp.2020.12.006. Epub 2020 Dec 26.

Outcomes of COVID-19 With the Mayo Clinic Model of Care and Research

John Charles O'Horo  1 , James R Cerhan  2 , Elliot J Cahn  2 , Philippe R Bauer  3 , Zelalem Temesgen  4 , Jon Ebbert  5 , Andy Abril  6 , Omar M Abu Saleh  4 , Mariam Assi  4 , Elie F Berbari  4 , Dennis M Bierle  7 , Wendelyn Bosch  8 , Charles D Burger  9 , Edison J Cano Cevallos  4 , Casey M Clements  10 , Eva M Carmona Porquera  1 , Natalia E Castillo Almeida  4 , Douglas W Challener  4 , Supavit Chesdachai  4 , Isin Y Comba  4 , Cristina G Corsini Campioli  4 , Sarah J Crane  5 , Ala S Dababneh  4 , Mark J Enzler  4 , Hind J Fadel  4 , Ravindra Ganesh  7 , Alice Gallo De Moraes  3 , John R Go  4 , Joel E Gordon  11 , Pooja R Gurram  4 , Pramod K Guru  12 , Erika L Halverson  4 , Michael F Harrison  13 , Heather A Heaton  10 , Ryan Hurt  7 , Mary J Kasten  4 , Augustine S Lee  9 , Emily R Levy  14 , Claudia R Libertin  8 , Jorge M Mallea  9 , William F Marshall 3rd  4 , Gautam Matcha  15 , Anne M Meehan  16 , Pablo Moreno Franco  12 , William G Morice 2nd  17 , Jennifer J O'Brien  18 , Richard Oeckler  19 , Steve Ommen  20 , Caitlin P Oravec  4 , Robert Orenstein  4 , Natalie J Ough  4 , Raj Palraj  4 , Bhavesh M Patel  21 , Vincent S Pureza  22 , Brian Pickering  23 , David M Phelan  4 , Raymund R Razonable  4 , Stacey Rizza  4 , Priya Sampathkumar  4 , Devang K Sanghavi  12 , Ayan Sen  21 , Jason L Siegel  24 , Kai Singbartl  25 , Aditya S Shah  4 , Fnu Shweta  4 , Leigh L Speicher  26 , Gina Suh  4 , Hussam Tabaja Jr  4 , Aaron Tande  4 , Henry H Ting  27 , Russell C Tontz 3rd  28 , James J Vaillant  4 , Paschalis Vergidis  4 , Mohamed Y Warsame  4 , Zachary A Yetmar  4 , Catherine Cate D Zomok  4 , Amy W Williams  29 , Andrew D Badley  30
Affiliations
Multicenter Study

Outcomes of COVID-19 With the Mayo Clinic Model of Care and Research

John Charles O'Horo et al. Mayo Clin Proc. 2021 Mar.

Abstract

Objective: To report the Mayo Clinic experience with coronavirus disease 2019 (COVID-19) related to patient outcomes.

Methods: We conducted a retrospective chart review of patients with COVID-19 diagnosed between March 1, 2020, and July 31, 2020, at any of the Mayo Clinic sites. We abstracted pertinent comorbid conditions such as age, sex, body mass index, Charlson Comorbidity Index variables, and treatments received. Factors associated with hospitalization and mortality were assessed in univariate and multivariate models.

Results: A total of 7891 patients with confirmed COVID-19 infection with research authorization on file received care across the Mayo Clinic sites during the study period. Of these, 7217 patients were adults 18 years or older who were analyzed further. A total of 897 (11.4%) patients required hospitalization, and 354 (4.9%) received care in the intensive care unit (ICU). All hospitalized patients were reviewed by a COVID-19 Treatment Review Panel, and 77.5% (695 of 897) of inpatients received a COVID-19-directed therapy. Overall mortality was 1.2% (94 of 7891), with 7.1% (64 of 897) mortality in hospitalized patients and 11.3% (40 of 354) in patients requiring ICU care.

Conclusion: Mayo Clinic outcomes of patients with COVID-19 infection in the ICU, hospital, and community compare favorably with those reported nationally. This likely reflects the impact of interprofessional multidisciplinary team evaluation, effective leveraging of clinical trials and available treatments, deployment of remote monitoring tools, and maintenance of adequate operating capacity to not require surge adjustments. These best practices can help guide other health care systems with the continuing response to the COVID-19 pandemic.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Study selection flowchart. aDeath during hospitalization or within 30 days of discharge (hospitalized patients) or within 30 days of coronavirus disease 2019 (COVID-10) diagnosis (outpatients). ICU, intensive care unit.
Figure 2
Figure 2
Geographic distribution of coronavirus disease 2019 (COVID-19) cases (N=7891), Mayo Clinic, March through July 2020.
Figure 3
Figure 3
Crude rates by month for National Institutes of Health Ordinal Scale outcomes (1-5) for 7891 patients, Mayo Clinic, March through July 2020.
See this image and copyright information in PMC

Comment in

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Berbari E.F., Williams A.W., Williamson M.J., Caine N.A., Nath K.A., Farrugia G. Mayo Clinic strategies for COVID-19: introduction. Mayo Clin Proc. 2020;95(9):S1–S2. - PMC - PubMed
    1. Shah A.S., Tande A.J., Challener D.W., O’Horo J.C., Binnicker M.J., Berbari E.F. Diagnostic stewardship: an essential element in a rapidly evolving COVID-19 pandemic. Mayo Clin Proc. 2020;95(9):S17–S19. - PMC - PubMed
    1. McBane R.D., Torres Roldan V.D., Niven A.S. Anticoagulation in COVID-19: a systematic review, meta-analysis and rapid guidance from the Mayo Clinic. Mayo Clin Proc. 2020;95(11):2467–2486. - PMC - PubMed
    1. Burger C.D., Mikhail A.E., Orenstein R., Ebbert J.O., Vergidis P., Badley A.D. Research response to SARS-CoV-2/COVID-19. Mayo Clin Proc. 2020;95(9):S52–S55. - PMC - PubMed
    1. Crane S.J., Ganesh R., Post J.A., Jacobson N.A. Telemedicine consultations and follow-up of patients with COVID-19. Mayo Clin Proc. 2020;95(9):S33–S34. - PMC - PubMed

Publication types