Review

. 2021 Apr;17(2):303-313.

doi: 10.1016/j.hfc.2021.01.003. Epub 2021 Feb 10.

Combined Effect of Mediterranean Diet and Aerobic Exercise on Weight Loss and Clinical Status in Obese Symptomatic Patients with Hypertrophic Cardiomyopathy

Giuseppe Limongelli¹, Emanuele Monda², Antonello D'Aponte³, Martina Caiazza², Marta Rubino², Augusto Esposito², Giuseppe Palmiero², Elisabetta Moscarella², Giovanni Messina³, Paolo Calabro'², Olga Scudiero⁴, Giuseppe Pacileo², Marcellino Monda³, Eduardo Bossone⁵, Sharlene M Day⁶, Iacopo Olivotto⁷

Affiliations

¹ Department of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", Via L. Bianchi, 80131 Naples, Italy; Institute of Cardiovascular Sciences, University College of London and St. Bartholomew's Hospital, Grower Street, London WC1E 6DD, UK. Electronic address: limongelligiuseppe@libero.it.
² Department of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", Via L. Bianchi, 80131 Naples, Italy.
³ Department of Experimental Medicine, Section of Human Physiology and Unit of Dietetics and Sports Medicine, University of Campania "Luigi Vanvitelli", Via Santa Maria di Costantinopoli, 80138 Naples, Italy.
⁴ Department of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II", Via G. Salvatore, 80138 Naples, Italy; CEINGE Advanced Biotechnologies, Via G. Salvatore, 80138 Naples, Italy; Task Force on Microbiome Studies, University of Naples "Federico II", Via G. Salvatore, 80138 Naples, Italy.
⁵ Division of Cardiology, Antonio Cardarelli Hospital, Via A. Cardarelli, 80131 Naples, Italy.
⁶ Department of Internal Medicine, University of Michigan, 500 S. State Street, Ann Arbor, MI 48109, USA.
⁷ Cardiomyopathy Unit and Genetic Unit, Careggi University Hospital, Largo Brambrilla, 50134 Florence, Italy.

PMID: 33673954
DOI: 10.1016/j.hfc.2021.01.003

Review

Combined Effect of Mediterranean Diet and Aerobic Exercise on Weight Loss and Clinical Status in Obese Symptomatic Patients with Hypertrophic Cardiomyopathy

Giuseppe Limongelli et al. Heart Fail Clin. 2021 Apr.

. 2021 Apr;17(2):303-313.

doi: 10.1016/j.hfc.2021.01.003. Epub 2021 Feb 10.

Authors

Affiliations

¹ Department of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", Via L. Bianchi, 80131 Naples, Italy; Institute of Cardiovascular Sciences, University College of London and St. Bartholomew's Hospital, Grower Street, London WC1E 6DD, UK. Electronic address: limongelligiuseppe@libero.it.
² Department of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", Via L. Bianchi, 80131 Naples, Italy.
³ Department of Experimental Medicine, Section of Human Physiology and Unit of Dietetics and Sports Medicine, University of Campania "Luigi Vanvitelli", Via Santa Maria di Costantinopoli, 80138 Naples, Italy.
⁴ Department of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II", Via G. Salvatore, 80138 Naples, Italy; CEINGE Advanced Biotechnologies, Via G. Salvatore, 80138 Naples, Italy; Task Force on Microbiome Studies, University of Naples "Federico II", Via G. Salvatore, 80138 Naples, Italy.
⁵ Division of Cardiology, Antonio Cardarelli Hospital, Via A. Cardarelli, 80131 Naples, Italy.
⁶ Department of Internal Medicine, University of Michigan, 500 S. State Street, Ann Arbor, MI 48109, USA.
⁷ Cardiomyopathy Unit and Genetic Unit, Careggi University Hospital, Largo Brambrilla, 50134 Florence, Italy.

PMID: 33673954
DOI: 10.1016/j.hfc.2021.01.003

Abstract

We evaluated the impact of weight loss (WL) using a Mediterranean diet and mild-to-moderate-intensity aerobic exercise program, on clinical status of obese, symptomatic patients with hypertrophic cardiomyopathy (HCM). Compared with nonresponders, responders showed a significant reduction of left atrial diameter, left atrial volume index (LAVI), E/E'average, pulmonary artery systolic pressure (PASP), and a significant increase in Vo_2max (%) and peak workload. Body mass index changes correlated with reduction in left atrial diameter, LAVI, E/E'average, PASP, and increase of Vo_2max (mL/Kg/min), Vo_2max (%), peak workload. Mediterranean diet and aerobic exercise is associated with clinical-hemodynamic improvement in obese symptomatic HCM patients.

Keywords: Aerobic exercise; Hypertrophic cardiomyopathy; Mediterranean diet; Obesity.

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Conflict of interest statement

Disclosure The authors have nothing to disclose.

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Combined Effect of Mediterranean Diet and Aerobic Exercise on Weight Loss and Clinical Status in Obese Symptomatic Patients with Hypertrophic Cardiomyopathy

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Combined Effect of Mediterranean Diet and Aerobic Exercise on Weight Loss and Clinical Status in Obese Symptomatic Patients with Hypertrophic Cardiomyopathy

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