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Multicenter Study
. 2021 Aug;36(8):1695-1700.
doi: 10.1007/s00384-021-03898-7. Epub 2021 Mar 5.

Prevalence of colorectal cancer and its precursor lesions in symptomatic patients under 55 years of age undergoing total colonoscopy: results of a large retrospective, multicenter, controlled endoscopy study

Katharina Stratmann  1 , Katarzyna Czerwinska  2 , Natalie Filmann  3 , Wolfgang Tacke  4 , Christoph Weber  4 , Herbert Bock  5 , Irina Blumenstein  2
Affiliations
Multicenter Study

Prevalence of colorectal cancer and its precursor lesions in symptomatic patients under 55 years of age undergoing total colonoscopy: results of a large retrospective, multicenter, controlled endoscopy study

Katharina Stratmann et al. Int J Colorectal Dis. 2021 Aug.

Abstract

Purpose: Colorectal cancer (CRC) is the second most common cancer in Germany. Around 60,000 people were diagnosed CRC in 2016 in Germany. Since 2019, screening colonoscopies are offered in Germany for men by the age of 50 and for women by the age of 55. It is recently discussed if women should also undergo a screening colonoscopy by the age of 50 and if there are any predictors for getting CRC.

Methods: Colonoscopies of 1553 symptomatic patients younger than 55 years were compared with colonoscopies of 1075 symptomatic patients older than 55 years. We analyzed if there are any significant differences between those two groups in the prevalence of CRC and its precursor lesions or between symptomatic men and women. We evaluated if there is a correlation between abdominal symptoms and the prevalence of CRC.

Results: In 164/1553 symptomatic patients, 194 (12.5%) polyps were detected. In total, six colorectal carcinomas (0.4%) were detected. There were no significant differences between men and women. In symptomatic patients ≥ 55 years, significantly more polyps were found (p<0.0001; 26.6% vs. 12.5%). Totally, 286 polyps (26.6%) were removed in 1075 symptomatic patients older than 55 years. Anorectal bleeding was the only abdominal symptom being a significant indicator for the prevalence of the occurrence of colon and rectum cancer in both groups (p=0.03, OR=2.73 95%-CI [1.11;6.70]), but with only low sensitivity (44%).

Conclusion: Due to no significant differences in men and women, we recommend screening colonoscopies also for women by the age of 50.

Keywords: Colorectal cancer; Lesions; Total colonoscopy.

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Conflict of interest statement

The authors declare that there are no conflicts of interest.

Figures

Fig. 1
Fig. 1
Age distribution of symptomatic patients
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References

    1. Kaatschet P (2019) Krebs in Deutschland 2015/2016. Hrsg.: Robert Koch-Institut, Gesellschaft der epidemiologischen Krebsregister in Deutschland e.V.
    1. Gerd Herold und Mitarbeiter (2020) Innere Medizin 2020. 490
    1. Selby JV, Friedman GD, Quesenberry CP, Weiss NS. A case–control study of screening sigmoidoscopy and mortality from colorectal cancer. N Engl J Med. 1992;326:653–657. doi: 10.1056/NEJM199203053261001. - DOI - PubMed
    1. Imperiale TF, Wagner DR, Lin CY, Larkin GN, Rogge JD, Ransohoff DF. Risk of advanced proximal neoplasms in asymptomatic adults according to the distal colorectal findings. N Engl J Med. 2000;343:169–174. doi: 10.1056/NEJM200007203430302. - DOI - PubMed
    1. Lieberman DA, Weiss DG, Bond JH, Ahnen DJ, Garewal H, Harford WV, Provenzale D, Sontag S, Schnell T, Durbin TE, Nelson DB, Ewing SL, Triadafilopoulos G, Ramirez FC, Lee JG, Collins JF, Fennerty MB, Johnston TK, Corless CL, McQuaid KR, Sampliner RE, Morales TG, Fass R, Smith R, Maheshwari Y, Chejfec G. Use of colonoscopy to screen asymptomatic adults for colorectal cancer. N Engl J Med. 2000;343:162–168. doi: 10.1056/NEJM200007203430301. - DOI - PubMed

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