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Review
. 2021 Jul;58(7):3290-3307.
doi: 10.1007/s12035-021-02311-2. Epub 2021 Mar 5.

Roles and Mechanisms of Axon-Guidance Molecules in Alzheimer's Disease

Lei Zhang  1 , Zhipeng Qi  1 , Jiashuo Li  1 , Minghui Li  1 , Xianchao Du  1 , Shuang Wang  1 , Guoyu Zhou  2 , Bin Xu  1 , Wei Liu  1 , Shuhua Xi  1 , Zhaofa Xu  1 , Yu Deng  3
Affiliations
Review

Roles and Mechanisms of Axon-Guidance Molecules in Alzheimer's Disease

Lei Zhang et al. Mol Neurobiol. 2021 Jul.

Abstract

Alzheimer's disease (AD) is a neurodegenerative disease that is characterized by progressive memory decline and cognitive dysfunctions. Although the causes of AD have not yet been established, many mechanisms have been proposed. Axon-guidance molecules play the roles in the occurrence and development of AD by participating in different mechanisms. Therefore, what roles do axon-guidance molecules play in AD? This study aimed at elucidating how axon-guidance molecules Netrins, Slits, Semaphorins, and Ephrins regulate the levels of Aβ, hyperphosphorylation of tau protein, Reelin, and other ways through different signaling pathways, in order to show the roles of axon-guidance molecules in the occurrence and development of AD. And it is hoped that this study can provide a theoretical basis and new perspectives in the search for new therapeutic targets for AD.

Keywords: Alzheimer’s disease; Ephrins; Netrins; Semaphorins; Slits.

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References

    1. Liu X, Hou D, Lin F, Luo J, Xie J, Wang Y, Tian Y (2019) The role of neurovascular unit damage in the occurrence and development of Alzheimer’s disease. Rev Neurosci 30(5):477–484. https://doi.org/10.1515/revneuro-2018-0056 - DOI - PubMed
    1. Zhuang QS, Zheng H, Gu XD, Shen L, Ji HF (2017) Detecting the genetic link between Alzheimer’s disease and obesity using bioinformatics analysis of GWAS data. Oncotarget 8(34)):55915–55919. https://doi.org/10.18632/oncotarget.19115 - DOI - PubMed - PMC
    1. Liu X, Chen K, Wu T, Weidman D, Lure F, Li J (2018) Use of multimodality imaging and artificial intelligence for diagnosis and prognosis of early stages of Alzheimer’s disease. Transl Res 194:56–67. https://doi.org/10.1016/j.trsl.2018.01.001 - DOI - PubMed - PMC
    1. Liu Y, Li Z, Ge Q, Lin N, Xiong M (2019) Deep feature selection and causal analysis of Alzheimer’s disease. Front Neurosci 13:1198. https://doi.org/10.3389/fnins.2019.01198 - DOI - PubMed - PMC
    1. Wang J, Gu BJ, Masters CL, Wang YJ (2017) A systemic view of Alzheimer disease - insights from amyloid-β metabolism beyond the brain. Nat Rev Neurol 13(10):612–623. https://doi.org/10.1038/nrneurol.2017.111 - DOI - PubMed

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