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Review
. 2021 May;38(3):643-646.
doi: 10.1111/pde.14555. Epub 2021 Mar 5.

Neonatal lupus erythematosus presenting as orolabial ulcerations: Two cases and a review of the literature

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Review

Neonatal lupus erythematosus presenting as orolabial ulcerations: Two cases and a review of the literature

Alex Drohan et al. Pediatr Dermatol. 2021 May.

Abstract

We report two unrelated infants who presented with orolabial ulcerations as a presenting manifestation of neonatal lupus erythematosus (NLE). Subsequent positive anti-SSA/SSB titers confirmed the diagnosis. In both infants, the ulcerations were painless and spontaneously resolved. NLE should be included in the differential diagnosis of orolabial ulcerations in the newborn, especially since mothers of affected infants may be asymptomatic.

Keywords: cutaneous; lupus; neonatal lupus; orolabial; ulceration.

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References

REFERENCES

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    1. Martin V, Lee LA, Askanase AD, Katholi M, Buyon JP. Long-term follow up of children with neonatal lupus and their unaffected siblings. Arthritis Rheum. 2002;46(9):2377-2383.
    1. Neiman AR, Lee LA, Weston WL, Buyon JP. Cutaneous manifestations of neonatal lupus without heart block: characteristics of mothers and children enrolled in a national registry. J Pediatr. 2000;137(5):674-680.
    1. Vanoni F, Lava SAG, Fossali EF, et al. Neonatal systemic lupus erythematosus syndrome: a comprehensive review. Clin Rev Allergy Immunol. 2017;53(3):469-476.
    1. Buyon JP, Clancy RM. Neonatal lupus: basic research and clinical perspectives. Rheum Dis Clin N Am. 2005;31:299-313.

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