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Comment
. 2021 Mar 6;6(1):112.
doi: 10.1038/s41392-021-00532-4.

Targeting glucose metabolism for treatment of COVID-19

Amin Ardestani  1   2 , Zahra Azizi  3
Affiliations
Comment

Targeting glucose metabolism for treatment of COVID-19

Amin Ardestani et al. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Proposed model of how glucose induced metabolic reviewing potentiates SARS-Cov-2 replication and cytokine production. In metabolically stressed monocytes (cultured under high glucose condition), SARS-CoV-2 infection enhances glycolysis by aberrant production of mitochondrial ROS which leads to activation of transcription factor hypoxia-inducible factor-1α (HIF-1α) to ensure its rapid replication. Such increased glucose metabolism through aerobic glycolysis fosters viral replication and cytokine production compromising T-cell response and function as well as induces lung epithelial cell death
See this image and copyright information in PMC

Comment on

  • Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis.
    Codo AC, Davanzo GG, Monteiro LB, de Souza GF, Muraro SP, Virgilio-da-Silva JV, Prodonoff JS, Carregari VC, de Biagi Junior CAO, Crunfli F, Jimenez Restrepo JL, Vendramini PH, Reis-de-Oliveira G, Bispo Dos Santos K, Toledo-Teixeira DA, Parise PL, Martini MC, Marques RE, Carmo HR, Borin A, Coimbra LD, Boldrini VO, Brunetti NS, Vieira AS, Mansour E, Ulaf RG, Bernardes AF, Nunes TA, Ribeiro LC, Palma AC, Agrela MV, Moretti ML, Sposito AC, Pereira FB, Velloso LA, Vinolo MAR, Damasio A, Proença-Módena JL, Carvalho RF, Mori MA, Martins-de-Souza D, Nakaya HI, Farias AS, Moraes-Vieira PM. Codo AC, et al. Cell Metab. 2020 Sep 1;32(3):437-446.e5. doi: 10.1016/j.cmet.2020.07.007. Epub 2020 Jul 17. Cell Metab. 2020. PMID: 32697943 Free PMC article.

References

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