Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Apr 6;143(14):1452-1454.
doi: 10.1161/CIRCULATIONAHA.120.051843. Epub 2021 Mar 8.

Risk of Coronary Artery Disease Conferred by Low-Density Lipoprotein Cholesterol Depends on Polygenic Background

Alessandro Bolli  1 , Paolo Di Domenico  1 , Roberta Pastorino  2 , George B Busby  3 , Giordano Bottà  1
Affiliations

Risk of Coronary Artery Disease Conferred by Low-Density Lipoprotein Cholesterol Depends on Polygenic Background

Alessandro Bolli et al. Circulation. .
No abstract available

Keywords: cardiovascular diseases; cholesterol; coronary artery disease.

PubMed Disclaimer

Figures

Figure.
Figure.
Association of PRS groups and LDL-C bins with CAD. Association of LDL-C levels with incident CAD in low PRS (first decile of PRS distribution), Int PRS (between the second and the ninth decile of PRS distribution), and high PRS (10th decile of PRS distribution). In each PRS group, the relative risk of CAD (HR) was calculated relative to the <100 mg/dL LDL-C reference level in a Cox proportional hazards model. The Cox proportional hazards model used time since study entry as the time scale (median follow-up period, 8.18 years) and was adjusted for the following control covariates: age, sex, genotyping array, the first 4 principal components of ancestry, Townsend deprivation index, diabetes, current smoking status, family history of heart disease, systolic blood pressure, glycohemoglobin, triglycerides, body mass index, C-reactive protein, lipoprotein(a), high-density lipoprotein cholesterol, and dietary antioxidant intake (total servings per day of fruits and vegetables). CAD indicates coronary artery disease; HR, hazard ratio; Int, intermediate; LDL-C, low-density lipoprotein cholesterol; and PRS, polygenic risk score.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Bycroft C, Freeman C, Petkova D, Band G, Elliott LT, Sharp K, Motyer A, Vukcevic D, Delaneau O, O’Connell J, et al. . The UK Biobank resource with deep phenotyping and genomic data. Nature. 2018;562:203–209. doi: 10.1038/s41586-018-0579-z - PMC - PubMed
    1. Inouye M, Abraham G, Nelson CP, Wood AM, Sweeting MJ, Dudbridge F, Lai FY, Kaptoge S, Brozynska M, Wang T, et al. ; UK Biobank CardioMetabolic Consortium CHD Working Group. Genomic risk prediction of coronary artery disease in 480,000 adults: implications for primary prevention. J Am Coll Cardiol. 2018;72:1883–1893. doi: 10.1016/j.jacc.2018.07.079 - PMC - PubMed
    1. Privé F, Vilhjálmsson BJ, Aschard H, Blum MGB. Making the most of clumping and thresholding for polygenic scores. Am J Hum Genet. 2019;105:1213–1221. doi: 10.1016/j.ajhg.2019.11.001 - PMC - PubMed
    1. Khera AV, Chaffin M, Aragam KG, Haas ME, Roselli C, Choi SH, Natarajan P, Lander ES, Lubitz SA, Ellinor PT, et al. . Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations. Nat Genet. 2018;50:1219–1224. doi: 10.1038/s41588-018-0183-z - PMC - PubMed
    1. Damask A, Steg PG, Schwartz GG, Szarek M, Hagström E, Badimon L. Patients with high genome-wide polygenic risk scores for coronary artery disease may receive greater clinical benefit from alirocumab treatment in the Odyssey Outcomes Trial. Circulation. 2020;141:624–636. doi: doi.org/10.1161/CIRCULATIONAHA.119.044434 - PubMed

Publication types

Substances