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. 2021 Apr 6;143(14):1452-1454.
doi: 10.1161/CIRCULATIONAHA.120.051843. Epub 2021 Mar 8.

Risk of Coronary Artery Disease Conferred by Low-Density Lipoprotein Cholesterol Depends on Polygenic Background

Alessandro Bolli  1 , Paolo Di Domenico  1 , Roberta Pastorino  2 , George B Busby  3 , Giordano Bottà  1
Affiliations

Risk of Coronary Artery Disease Conferred by Low-Density Lipoprotein Cholesterol Depends on Polygenic Background

Alessandro Bolli et al. Circulation. .
No abstract available

Keywords: cardiovascular diseases; cholesterol; coronary artery disease.

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Figures

Figure.
Figure.
Association of PRS groups and LDL-C bins with CAD. Association of LDL-C levels with incident CAD in low PRS (first decile of PRS distribution), Int PRS (between the second and the ninth decile of PRS distribution), and high PRS (10th decile of PRS distribution). In each PRS group, the relative risk of CAD (HR) was calculated relative to the <100 mg/dL LDL-C reference level in a Cox proportional hazards model. The Cox proportional hazards model used time since study entry as the time scale (median follow-up period, 8.18 years) and was adjusted for the following control covariates: age, sex, genotyping array, the first 4 principal components of ancestry, Townsend deprivation index, diabetes, current smoking status, family history of heart disease, systolic blood pressure, glycohemoglobin, triglycerides, body mass index, C-reactive protein, lipoprotein(a), high-density lipoprotein cholesterol, and dietary antioxidant intake (total servings per day of fruits and vegetables). CAD indicates coronary artery disease; HR, hazard ratio; Int, intermediate; LDL-C, low-density lipoprotein cholesterol; and PRS, polygenic risk score.
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