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Editorial
. 2021 Feb 18:12:646596.
doi: 10.3389/fimmu.2021.646596. eCollection 2021.

Editorial: Innate Immunity in Normal and Adverse Pregnancy

Richard M Burwick  1 , A Inkeri Lokki  2   3   4 , Sherry D Fleming  5 , Jean F Regal  6
Affiliations
Editorial

Editorial: Innate Immunity in Normal and Adverse Pregnancy

Richard M Burwick et al. Front Immunol. .
No abstract available

Keywords: complement; infection; innate immunity; innate lymphoid cells; pregnancy.

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Conflict of interest statement

Alexion Pharmaceuticals has supported speaking fees (AL and RB) and research grants (RB) in the past. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Regulation of the innate immune response influences pregnancy outcomes. When regulated, complement and the innate immune cells, including macrophages, neutrophils, and innate lymphoid cells, control infection and promote a successful pregnancy. Excessive or dysregulated innate responses due to uncontrolled infection, autoimmune disease, genetic predisposition, or other risk factors result in adverse pregnancy outcomes. Size depicts the magnitude of infection and/or activation of the innate immune response. Created with biorender.com.
See this image and copyright information in PMC

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References

    1. Makatsariya AD, Slukhanchuk EV, Bitsadze VO, Khizroeva JKH, Tretyakova MV, Tsibizova VI, et al. . Thrombotic microangiopathy, DIC-syndrome and COVID-19: link with pregnancy prothrombotic state. J Matern Fetal Neonatal Med. (2020) 1–9. 10.1080/14767058.2020.1786811 - DOI - PubMed
    1. Rodrigues C, Baia I, Domingues R, Barros H. Pregnancy and breastfeeding during COVID-19 pandemic: a systematic review of published pregnancy cases. Front Public Health. (2020) 8:558144. 10.3389/fpubh.2020.558144 - DOI - PMC - PubMed
    1. Regal JF, Gilbert JS, Burwick RM. The complement system and adverse pregnancy outcomes. Mol Immunol. (2015) 67:56–70. 10.1016/j.molimm.2015.02.030 - DOI - PMC - PubMed
    1. Kim MY, Guerra MM, Kaplowitz E, Laskin CA, Petri M, Branch DW, et al. . Complement activation predicts adverse pregnancy outcome in patients with systemic lupus erythematosus and/or antiphospholipid antibodies. Ann Rheum Dis. (2018) 77:549–55. 10.1136/annrheumdis-2017-212224 - DOI - PMC - PubMed
    1. Vivier E, Artis D, Colonna M, Diefenbach A, Di Santo JP, Eberl G, et al. . Innate lymphoid cells: 10 years on. Cell. (2018) 174:1054–66. 10.1016/j.cell.2018.07.017 - DOI - PubMed

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