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. 2021 Mar-Apr;37(2):483-488.
doi: 10.12669/pjms.37.2.2787.

A comparison of ketamine-midazolam combination and propofol-fentanyl combination on procedure comfort and recovery process in pediatric colonoscopy procedures

Sedat Saylan  1 , Ulas Emre Akbulut  2
Affiliations

A comparison of ketamine-midazolam combination and propofol-fentanyl combination on procedure comfort and recovery process in pediatric colonoscopy procedures

Sedat Saylan et al. Pak J Med Sci. 2021 Mar-Apr.

Abstract

Objective: To compare the efficacy and safety of midazolam-ketamine combination versus fentanyl-propofol combination in pediatric diagnostic colonoscopy.

Methods: This is a retrospective study of 68 children undergoing diagnostic gastroenterology with midazolam-ketamine combination (Group-K) or with fentanyl-propofol combination (Group-P) in the pediatric gastroentology department at a Turkish tertiary hospital between January 2015 and June 2017. An intravenous midazolam was administered one minute before ketamine administration in Group K. Intravenous fentanyl was given to Group P, followed by intravenous propofol.

Results: There were statistically no significant differences between the groups as for age, gender, weight, duration of colonoscopy and complications observed during procedure. Ramsay sedation score was significantly higher in Group K. Recovery time and the rate of complications during the recovery of Group-K (23 patients, 65.7%) was significantly higher than that of Group P (8 patients, 24.2%) (p= 0.001).

Conclusions: Colonoscopy procedures can be quite comfortable in children when using the midazolam-ketamine combination. However, adverse effects related to ketamine were observed during recovery.

Keywords: Child; Colonoscopy; Ketamine; Propofol; Sedation.

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Fig.1
Flow chart of the study.
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References

    1. das Neves JF, das Neves Araujo MM, de Paiva Araujo F, Ferreira CM, Duarte FB, Pace FH, et al. Colonoscopy Sedation:Clinical Trial Comparing Propofol and Fentanyl With or Without Midazolam. Braz J Anesthesiol. 2016;66:231–236. doi:10.1016/j.bjane.2014.09.014. - PubMed
    1. Jalowiecki P, Rudner R, Gonciarz M, Kawecki P, Petelenz M, Dziurdzik P. Sole use of dexmedetomidine has limited utility for conscious sedation during outpatient colonoscopy. Anesthesiology. 2005;103:269–273. doi:10.1097/00000542-200508000-00009. - PubMed
    1. Mahoney LB, Lightdale JR. Sedation of the pediatric and adolescent patient for GI procedures. Curr Treat Options Gastroenterol. 2007;10:412–421. doi:10.1007/s11938-007-0041-z. - PubMed
    1. Akbulut UE, Saylan S, Sengu B, Akcali GE, Erturk E, Cakir M. A comparison of sedation with midazolam-ketamine versus propofol-fentanyl during endoscopy in children:a randomized trial. Eur J Gastroenterol Hepatol. 2017;29:112–118. doi:10.1097/MEG.0000000000000751. - PMC - PubMed
    1. Damps M, Stołtny L, Siemek-Mitela J, Lekstan A, Krzych Ł, Kucewicz-Czech E. Comparison of Propofol-Ketamine Versus Propofol-Remifentanil in Children Anaesthetized for Gastroscopy. Anaesthesiol Intensive Ther. 2019;51:262–267. doi:10.5114/ait.2019.88185. - PubMed

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