Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2021 Mar-Apr;37(2):598-599.
doi: 10.12669/pjms.37.2.3522.

Fondaparinux-associated Thrombocytopenia

Jahanzeb Malik  1 , Nismat Javed  2 , Matiullah Kamin  3
Affiliations
Case Reports

Fondaparinux-associated Thrombocytopenia

Jahanzeb Malik et al. Pak J Med Sci. 2021 Mar-Apr.

Abstract

Heparin-induced thrombocytopenia (HIT) is an immune-mediated condition causing thrombocytopenia and paradoxical thrombosis after exposure to heparin or low-molecular-weight heparin. It has been rarely reported by Fondaparinux, an artificial pentasaccharide similar to heparin. This manuscript presents a case of HIT associated with fondaparinux use.

Keywords: Factor Xa inhibitor; Fondaparinux-associated thrombocytopenia; HIT.

PubMed Disclaimer

Conflict of interest statement

Conflict of interests: None.

References

    1. Patriarcheas V, Pikoulas A, Kostis M, Charpidou A, Dimakakos E. Heparininduced Thrombocytopenia:Pathophysiology, Diagnosis and Management. Cureus. 2020;12(3):e7385. doi:10.7759/cureus.7385. - PMC - PubMed
    1. Tardy B, Lecompte T, Mullier F, Vayne C, Pouplard C. Detection of Platelet-Activating Antibodies Associated with Heparin-Induced Thrombocytopenia. J Clin Med. 2020;9(4):1226. doi:10.3390/jcm9041226. - PMC - PubMed
    1. Gruel Y, De Maistre E, Pouplard C, Mullier F, Susen S, Roullet S, et al. Diagnosis and management of heparin-induced thrombocytopenia. Anaesth Crit Care Pain Med. 2020;39(2):291–310. - PubMed
    1. Kounis NG, Koniari I, Soufras GD, Tsigkas G, Plotas P, Davlouros P, et al. The paradox of heparin induced thrombocytopenia-thrombosis, the role of fondaparinux and the need for new therapeutic strategies. Int Angiol. 2020;39(4):350–351. doi:10.23736/S0392-9590.20.04364-3. - PubMed
    1. Khodabandeh S, Biancari F, Kinnunen EM, Mariscalco G, Airaksinen J, Gherli R, et al. Perioperative Bleeding in Patients With Acute Coronary Syndrome Treated With Fondaparinux Versus Low-Molecular-Weight Heparin Before Coronary Artery Bypass Grafting. Am J Cardiol. 2019;123(4):565–570. doi:10.1016/j.amjcard.2018.11.028. - PubMed

Publication types

LinkOut - more resources