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Review
. 2021 Feb 18:2021:8836117.
doi: 10.1155/2021/8836117. eCollection 2021.

Efficacy of Longdan Xiegan Decoction on the Treatment of Eczema: A Systematic Review and Meta-Analysis

Ziteng Hu  1 , Lidong Gao  1 , Chengxian Li  1 , Alberto Cucco  1 , Shang Wang  1 , Weiling Yuan  1 , Fan Zhang  1 , Shuai Kang  1 , Min Wang  1
Affiliations
Review

Efficacy of Longdan Xiegan Decoction on the Treatment of Eczema: A Systematic Review and Meta-Analysis

Ziteng Hu et al. Evid Based Complement Alternat Med. .

Abstract

Background: Longdan Xiegan decoction (LDXGD) has been widely used in the treatment of eczema. In recent years, randomized controlled trials (RCTs) of LDXGD for the treatment of eczema have gradually increased. Most of the results show that LDXGD is effective in treating eczema. However, whether these conclusions are reliable or not requires meta-analysis.

Objective: This study aimed to systematically evaluate the clinical efficacy of LDXGD in the treatment of eczema.

Materials and methods: Seven electronic databases, including PubMed, Excerpta Medica Database (EMBASE), Cochrane Library, Chinese Biomedical Literature on Disc (CBM), China National Knowledge Infrastructure (CNKI), WanFang, and Chinese Science and Technology Periodical Database (VIP) were systematically searched from their inception until January 2021. Risk of bias was assessed using criteria from the Cochrane Collaboration and meta-analysis was conducted on the screened literature data using Review Manage (RevMan 5.3). Then, to assess the quality of evidence, the GRADE criteria was adopted.

Results: 14 RCTs with 1080 participants were identified. Meta-analysis indicated that compared with western medicine (WM), the cure rate and the total effective rate of LDXGD in treating eczema were higher. Meanwhile, the recurrence rate and the levels of interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor (TNF-α) after treatment were lower. The adverse reaction was reported in 5 out of 14 studies without significant statistical difference. According to GRADE criteria, the quality of evidence was low for all outcomes except for the cure rate (moderate-quality evidence) and the total effective rate (moderate-quality evidence).

Conclusion: The clinical efficacy of LDXGD in the treatment of eczema was more effective compared with the one of conventional WM alone. However, due to the limitation of the quality of the included studies, additional studies are required to further confirm these results.

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Conflict of interest statement

The author declares that there are no conflicts of interest in this article.

Figures

Figure 1
Figure 1
Inclusion process and results of the relevant articles.
Figure 2
Figure 2
Risk of bias graph of the 14 articles.
Figure 3
Figure 3
Risk of bias summary graph of the 14 articles.
Figure 4
Figure 4
Forest plot and meta-analysis of the cure rate.
Figure 5
Figure 5
Forest plot and meta-analysis of the total effective rate.
Figure 6
Figure 6
Forest plot and meta-analysis of the recurrence rate.
Figure 7
Figure 7
Forest plot and meta-analysis of the adverse reaction rate.
Figure 8
Figure 8
Funnel plot of the cure rate.
Figure 9
Figure 9
Funnel plot of the total effective rate.
See this image and copyright information in PMC

References

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