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. 1988 Feb-Mar;11(2):69-72.
doi: 10.1016/0143-4179(88)90012-1.

Haematological changes induced by the intravenous injection of CCK-8 in rats subjected to haemorrhagic shock

S Guarini  1 , C Bazzani, L Leo, A Bertolini
Affiliations

Haematological changes induced by the intravenous injection of CCK-8 in rats subjected to haemorrhagic shock

S Guarini et al. Neuropeptides. 1988 Feb-Mar.

Abstract

In rats bled to invariably fatal haemorrhagic shock (mean arterial pressure = 18-24 mmHg), the prompt and sustained improvement of cardiovascular function, obtained with the i.v. injection of cholecystokinin octapeptide (CCK-8, 20 g/kg) is associated with a massive increase in the volume of residual circulating blood (0.69 +/- 0.12 ml/100 g b.w. in saline-treated rats; 1.61 +/- 0.09 ml/100 g b.w. in CCK-8-treated rats). The number of red cells/mm3 and the % Hb content is the same in CCK-8-treated and in control rats. So, in a condition of severe haemorrhage, otherwise incompatible with survival, the i.v. injection of CCK-8 not only induces an impressive increase in arterial pressure and in circulating blood volume, but also greatly improves tissue oxygenation.

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