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Review
. 2021 Feb 17:10:614122.
doi: 10.3389/fcimb.2020.614122. eCollection 2020.

Parasite-Host Interaction and Pathophysiology Studies of the Human Relapsing Malarias Plasmodium vivax and Plasmodium ovale Infections in Non-Human Primates

Erica M Pasini  1 , Clemens H M Kocken  1
Affiliations
Review

Parasite-Host Interaction and Pathophysiology Studies of the Human Relapsing Malarias Plasmodium vivax and Plasmodium ovale Infections in Non-Human Primates

Erica M Pasini et al. Front Cell Infect Microbiol. .

Abstract

Malaria remains a serious health concern across the globe. Historically neglected, non-Falciparum human malarias were put back on the agenda by a paradigm shift in the fight against malaria from malaria control to malaria eradication. Here, we review the modeling of the relapsing parasites Plasmodium vivax (P. vivax) and Plasmodium ovale (P. ovale) in non-human primates with a specific focus on the contribution of these models to our current understanding of the factors that govern parasite-host interactions in P. vivax and P. ovale parasite biology and pathophysiology.

Keywords: Plasmodium ovale; Plasmodium vivax; malaria pathophysiology; parasite biology; parasite-host interactions; relapsing malarias.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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