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Review
. 2021 Dec;20(12):3793-3801.
doi: 10.1111/jocd.14047. Epub 2021 Mar 19.

Mechanism and clinical applications of needle-free injectors in dermatology: Literature review

Hye Sung Han  1 , Ji Yeon Hong  2 , Tae Rin Kwon  1 , Sung Eun Lee  1 , Kwang Ho Yoo  1 , Sun Young Choi  3 , Beom Joon Kim  1
Affiliations
Review

Mechanism and clinical applications of needle-free injectors in dermatology: Literature review

Hye Sung Han et al. J Cosmet Dermatol. 2021 Dec.

Abstract

Background: Needle-free jet injectors are devices that deliver drugs using a high-speed jet without a needle. Recent studies have significantly increased our understanding of the mechanisms of needle-free jet injectors, and technical advancements have broadened the scope of application of the device.

Aims: We aimed to provide an up-to-date review of previous literature regarding the mechanism of action and clinical applications of needle-free jet injectors in dermatology field.

Methods: We conducted a PUBMED search for studies on needle-free jet injectors using the following parameters: "Pneumatic injector" OR "needleless injector" OR "needle-free injector" OR "jet injector." Among 191 results, 72 articles focusing on their mechanisms of action, cutaneous delivery patterns, and clinical applications in dermatology were selected for review.

Results: Significant clinical evidence has been published confirming the potential of needle-free jet injectors in treating various dermatologic conditions. In particular, these devices have the potential to be used in various skin remodeling treatment, especially in skin rejuvenation procedures by injecting various esthetic materials.

Conclusion: As proven by accumulated experience, the applications of NFJIs are not restricted to vaccine or insulin delivery in dermatology field. However, this literature review shows that until now, there are no clinical guidelines that standardize the optimal parameters when using NFJIs on various clinical settings. Therefore, further studies should be performed in order to investigate the full potential of these devices in dermatology, to ensure safe and effective outcomes in clinical practice.

Keywords: jet injector; needle-free injector; pneumatic injector.

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References

REFERENCES

    1. Mohizin A, Kim JK. Current engineering and clinical aspects of needle-free injectors: a review. J Mech Sci Technol. 2018;32(12):5737-5747.
    1. Bremseth DL, Pass F. Delivery of insulin by jet injection: recent observations. Diabetes Technol Ther. 2001;3(2):225-232.
    1. Mitragotri S. Current status and future prospects of needle-free liquid jet injectors. Nat Rev Drug Discov. 2006;5(7):543-548.
    1. Stachowiak JC, Li TH, Arora A, Mitragotri S, Fletcher DA. Dynamic control of needle-free jet injection. J Control Release. 2009;135(2):104-112.
    1. Levenberg A, Halachmi S, Arad-Cohen A, Ad-El D, Cassuto D, Lapidoth M. Clinical results of skin remodeling using a novel pneumatic technology. Int J Dermatol. 2010;49(12):1432-1439.

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