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. 2021 Apr;103(4):235-244.
doi: 10.1308/rcsann.2020.7137. Epub 2021 Mar 8.

Diversion, resection, or stenting as a bridge to surgery for acute neoplastic left-sided colonic obstruction: a systematic review and network meta-analysis of studies with curative intent

P Gavriilidis  1 , N de'Angelis  2 , J Wheeler  3 , A Askari  4 , S Di Saverio  5 , J R Davies  3
Affiliations

Diversion, resection, or stenting as a bridge to surgery for acute neoplastic left-sided colonic obstruction: a systematic review and network meta-analysis of studies with curative intent

P Gavriilidis et al. Ann R Coll Surg Engl. 2021 Apr.

Abstract

Introduction: The debate on the best surgical management strategy for acute malignant left-sided colonic obstruction is ongoing. Decompressing colostomy (DC) and stenting as a bridge to surgery (SBTS) are the currently proposed alternative approaches to emergency colectomy (EC). However, the results of a traditional meta-analysis were inconclusive. Therefore, a network meta-analysis (NMA) was conducted to compare the three approaches for acute left-sided colonic obstruction.

Methods: A systematic literature search of Embase, PubMed, Google Scholar and the Cochrane library was performed. A traditional meta-analysis and subsequent NMA were conducted.

Findings: A significantly greater number of primary anastomoses were performed in the DC cohort than in the EC and SBTS cohorts. The 90-day mortality rate was significantly lower in the DC cohort than in the EC and SBTS cohorts. Higher costs were associated with the SBTS cohort (by US$2,000) than with the EC cohort. The locoregional recurrence rate was higher for the SBTS cohort than for the EC cohort.

Conclusions: Evidence from the first NMA suggests there may be some clinical advantages associated with DC as an alternative approach to the EC and SBTS approaches for adequately selected patients with malignant large bowel obstruction.

Keywords: Acute colectomy; Acute resection; Colonic obstruction; Diversion; Endoluminal stenting.

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Conflict of interest statement

All named authors hereby declare that they have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Diagram of search strategy
Figure 2
Figure 2
Forest plots of NMA age, permanent stoma, primary resection anastomosis, mortality. CrI = credible interval.
Figure 3
Figure 3
NMA league table comparing all three treatment modalities in terms of outcomes. CI = confidence interval; DC = decompressing colostomy; EC = emergency colectomy; NMA = network meta-analysis; OR = odds ratio; SBTS = stenting as a bridge to surgery.
See this image and copyright information in PMC

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