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Meta-Analysis
. 2021 Mar;49(3):300060521993312.
doi: 10.1177/0300060521993312.

Value of HMGB1 expression for assessing gastric cancer severity: a systematic meta-analysis

Chunxiang Zhou  1   2 , Qun Yang  1   3
Affiliations
Meta-Analysis

Value of HMGB1 expression for assessing gastric cancer severity: a systematic meta-analysis

Chunxiang Zhou et al. J Int Med Res. 2021 Mar.

Abstract

Objective: To evaluate the clinical value of high mobility group box-1 (HMGB1) expression levels in patients with gastric cancer.

Methods: Articles published from January 2000 to August 2022 were searched using PubMed, Google Scholar and Science Direct, Springer, Wiley and NIH to evaluate the clinicopathological significance of HMGB1 expression in gastric cancer.

Results: A total of 156 publications were selected, of which six studies, comprising 846 patients, met the criteria for inclusion in this study. Forest plots of clinicopathological characteristics indicated that HMGB1 expression was not associated with age (odds ratio (OR) = 1.07, 95% confidence interval (CI): 0.89-1.28), sex (OR = 0.90, 95% CI: 0.81-1.00), TNM (OR = 1.39, 95% CI: 0.82-2.37), N stage (OR = 1.42, 95% CI: 0.97-2.07), or tumor differentiation (OR = 0.96, 95% CI: 0.71-1.29), but was highly correlated with pT stage (OR = 1.56, 95% CI: 1.17-2.07). Funnel plots showed no significant publication bias in the included studies in terms of age, sex, TNM, pT stage, N stage, or tumor differentiation.

Conclusion: HMGB1 expression was significantly correlated with tumor pT stage, but not with age, sex, TNM stage, tumor N stage, tumor differentiation, or lymphatic metastasis in patients with GC.

Keywords: Forest plot; Gastric cancer; HMGB1; pT stage; prognosis; tumor stage.

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Conflict of interest statement

Declaration of conflicting interest: The authors declare that there is no conflict of interest.

Figures

Figure 1.
Figure 1.
Flow chart of selection of publications for inclusion in the study.
Figure 2.
Figure 2.
Forest plot evaluating association of HMGB1 expression with age. RR, relative risk; CI, confidence interval.
Figure 3.
Figure 3.
Forest plot evaluating association of HMGB1 expression with sex. RR, relative risk; CI, confidence interval.
Figure 4.
Figure 4.
Forest plot evaluating association of HMGB1 expression with TNM. RR, relative risk; CI, confidence interval.
Figure 5.
Figure 5.
Forest plot evaluating association of HMGB1 expression with N stage. RR, relative risk; CI, confidence interval.
Figure 6.
Figure 6.
Forest plot evaluating association of HMGB1 expression with histologic grade. RR, relative risk; CI, confidence interval.
Figure 7.
Figure 7.
Forest plot evaluating association of HMGB1 expression with pT stage. RR, relative risk; CI, confidence interval.
Figure 8.
Figure 8.
Funnel plot of studies used in the analysis of age. se, standard error; RR, relative risk; OR, odds ratio.
Figure 9.
Figure 9.
Funnel plot of studies used in the analysis of sex. se, standard error; RR, relative risk; OR, odds ratio.
Figure 10.
Figure 10.
Funnel plot of studies used in the analysis of TNM. se, standard error; RR, relative risk; OR, odds ratio.
Figure 11.
Figure 11.
Funnel plot of studies used in the analysis of N stage. se, standard error; RR, relative risk; OR, odds ratio.
Figure 12.
Figure 12.
Funnel plot of studies used in the analysis of histologic grade. se, standard error; RR, relative risk; OR, odds ratio.
Figure 13.
Figure 13.
Funnel plot of studies used in the analysis of pT stage. se, standard error; RR, relative risk; OR, odds ratio.
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