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. 2020 Nov 9;92(1):e2021019.
doi: 10.23750/abm.v92i1.9327.

Investigating changes in calcium, phosphorus, alkaline phosphatase, and 25-hydroxy Vitamin D after surgical repair of fractures of femur or tibia

Amir Sobhani Eraghi  1 , Saba Saberi  2 , Borzouyeh Molazemsanandaji  3 , Alireza Ghaznavi  4
Affiliations

Investigating changes in calcium, phosphorus, alkaline phosphatase, and 25-hydroxy Vitamin D after surgical repair of fractures of femur or tibia

Amir Sobhani Eraghi et al. Acta Biomed. .

Abstract

Background: The recovery of long bones after fracture requires a specific process to restore the natu-ral bone anatomy as well as its proper function. Changes in calcium, phosphorus, alkaline phosphatase and 25-hydroxy vitamin D can be justified either in the fracture process or in the repair procedure. The aim of this sectional study is to investigate changes in all these compounds after the surgical repair of fractures of femur and tibia bones.

Materials and methods: A random sample of 68 patients was selected from whom referring to a hospital with fractures of femur or tibia and candidate for repair surgery. The mentioned bone markers were measured at the time after surgery, six and twelve weeks after the surgery with laboratory-specific kits. A p-value, lower than 0.05, was considered to be statistically significant.

Result: Of the patients, 34 were with fractures of femur and 34 were with fractures of tibia, equally. The patients were aged 2 to 69 with a mean age of 27.93 ± 14.8 years old. The means of calcium (p = 0.001) and phosphorus (p = 0.014) at three intervals were statistically significant difference. In contrast, the means serum alkaline phosphatase and vitamin D levels did not show any significant changes over time (p = 0.042).

Conclusion: In conclusion, the means of calcium and phosphorus over the follow-up were statistically significant. The observed difference of vitamin D after the surgery, as well the level of alkaline phosphatase for femoral fracture between male and female are one of our important findings. (www.actabiomedica.it).

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Conflict of interest statement

Each author declares that he or she has no commercial associations (e.g. consultancies, stock ownership, equity interest, patent/licensing arrangement etc.) that might pose a conflict of interest in connection with the submitted article

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