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Review
. 2020 Oct 13;92(1):e2021018.
doi: 10.23750/abm.v92i1.9904.

Jawbone fibrous dysplasia: retrospective evaluation in a cases series surgically treated and short review of the literature

Gino Amleto Pacino  1 , Salvatore Cocuzza  2 , Giovanni Tonoli  3 , Paolo Boscolo Rizzo  4 , Giancarlo Tirelli  5 , Margherita Tofanelli  6 , Giorgio Ciprandi  7 , Ignazio La Mantia  8 , Antonino Maniaci  9 , Maria Cristina Da Mosto  10 , Giacomo Spinato  11
Affiliations
Review

Jawbone fibrous dysplasia: retrospective evaluation in a cases series surgically treated and short review of the literature

Gino Amleto Pacino et al. Acta Biomed. .

Abstract

Background and aim of the work: Fibrous dysplasia is a fibro-osseous osteopathy in which the normal bone architecture is replaced by fibrous tissue and non-functional trabeculae-like osseous structures. In head and neck area monostotic or polyostotic lesions cause a progressively expanding destructive bone swelling producing cosmetic deformities and functional impairments. The aim of this article is to present a retrospective review of a clinical case series with pathologically confirmed jawbone fibrous dysplasia for over an 8-year-period.

Material and methods: Clinical presentation and radiographic features of fibrous dysplasia affecting the jawbone skeletal area, surgical procedures performed including the reconstructive methods employed and clinical outcomes were analysed for each patient.

Results: Seven cases were classified as having monostotic fibrous dysplasia while the others four cases were classified as having polyostotic form. The mandible was most commonly involved. The most common presenting features included marked facial deformity, intraoral bulging, malocclusion and dental alterations. Aesthetic and/or functional impairments were the major indications for surgical treatment in all the patients of this series. Six patients underwent bone remodelling while in the remaining cases subtotal or total resection was performed. Bone reconstruction by means of autologous free bone grafts or revascularized free bone flaps was made in three cases.

Conclusion: The choice of the tailored therapeutic approach should be evaluated according the patient's age, rate of growth, anatomic location, type of involvement and the presence or not of functional disturbances and cosmetic alterations. Surgery remains the best therapeutic option.

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Conflict of interest statement

Each author declares that he or she has no commercial associations ( consultancies, stock ownership, equity interest, patent/licensing arrangement etc.) that might pose a conflict of interest in connection with the submitted article”.

Figures

Figure 1.
Figure 1.
Coronal computed tomography (CT) scan shows a pagetoid-like lesion of the left maxillo-malar bone
Figure 2.
Figure 2.
Coronal tomography dental scan scan showing a left mandibular bone lesion with cotton-wool appearence
Figure 3.
Figure 3.
Three-Dimensional computed tomography scan of the mandible. The exam shows a lesion enlarging the left mandibular body
Figure 4.
Figure 4.
Axial Computed Tomography (CT) scan showing an extensive hyperostosing of sclerotic type of the right facial bones
Figure 5.
Figure 5.
Antero-posterior Radiograph showing a ground-glass opacification of the left maxillary bone
See this image and copyright information in PMC

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References

    1. Neville BD, Damm DD, Allen CM, Bouquot JE. Oral and maxillofacial pathology. II ed. Philadelphia: WB Saunders Company; 2002. Bone pathology; pp. 553–557.
    1. Eversole LR, Sabes WB, Povin S. Fibrous dysplasia, a nosologic problem in the diagnosis of fibro-osseous lesions of the jaws. J Oral Pathol. 1972;1:189–220. - PubMed
    1. Waldron CA. Fibro-osseous lesions of the jaws. J Oral Maxillofac Surg. 1993;51:828–835. - PubMed
    1. Gorlin RJ, Cohen MM, Levin LS, editors. New York: Oxford University Press; 1990. Syndromes of the head and neck, 3rd ed.
    1. Lichteinstein L. Polyostotic fibrous dysplasia. Arch Surg. 1938;36:874–898.