Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Aug;56(4):735-745.
doi: 10.1111/jre.12870. Epub 2021 Mar 8.

Resveratrol enhances bone formation by modulating inflammation in the mouse periodontitis model

Nirpesh Adhikari  1 , Yam Prasad Aryal  1 , Jae-Kwang Jung  2 , Jung-Hong Ha  3 , So-Young Choi  4 , Ji-Youn Kim  5 , Tae-Hoon Lee  6 , Sang-Hyun Kim  7 , Hitoshi Yamamoto  8 , Jo-Young Suh  9 , Chang-Hyeon An  10 , Youngkyun Lee  1 , Wern-Joo Sohn  11 , Seo-Young An  10 , Jae-Young Kim  1
Affiliations

Resveratrol enhances bone formation by modulating inflammation in the mouse periodontitis model

Nirpesh Adhikari et al. J Periodontal Res. 2021 Aug.

Abstract

Objective: To evaluate the effect of resveratrol on periodontal bone regeneration after local delivery and to determine its effect on inflammatory mediators.

Background: Resveratrol is considered an anti-inflammatory polyphenolic stilbene involved in the modulation of inflammation.

Materials and methods: Periodontitis was induced in mouse molars using a 5-day ligature model followed by the left second molar extraction and 50 µM resveratrol treatment for 1 and 2 weeks. We then examined specimens treated for 1 week histologically and with immunostaining. Microfocus-computed tomography (micro-CT) was used to examine the bone volume formation.

Results: After 1 week of treatment, proinflammatory cytokine levels (TNF-alpha and IL6), cells exhibiting neutrophil and macrophage marker (MPO), cell proliferation marker (Ki67), and preosteoblastic marker (RUNX2) reactivity decreased in the resveratrol-treated specimens compared to the control group. In contrast, we observed a higher number of CD31-, F4/80-, and osteocalcin- (OCN-) positive cells in the resveratrol-treated specimens. After 2 weeks, micro-CT confirmed an increased bone mass in the region of the extraction socket in the resveratrol-treated group.

Conclusion: After 1 week, the resveratrol-treated specimens revealed evidence of inflammation modulation compared to the control group. These data suggest that resveratrol not only affects inflammation control but also is useful for treating periodontitis-related tissue defects and bone regeneration.

Keywords: bone regeneration; cytokine; inflammation; periodontitis model; tooth loss.

PubMed Disclaimer

References

REFERENCES

    1. Chen J. Food oral processing-a review. Food Hydrocoll. 2009;23(1):1-25.
    1. Agrawal A, Rai TP. Role of mastication in the digestion process: a review. J Chronother Drug Deliv. 2016;7(1):21-24.
    1. Kayal RA. The role of osteoimmunology in periodontal disease. Biomed Res Int. 2013;2013:639368.
    1. Pihlstrom BL, Michalowicz BS, Johnson NW. Periodontal diseases. Lancet. 2005;366(9499):1809-1820.
    1. Hasturk H, Kantarci A. Activation and resolution of periodontal inflammation and its systemic impact. Periodontol 2000. 2015;69(1):255-273.

LinkOut - more resources