Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2021 May 1;78(5):524-526.
doi: 10.1001/jamaneurol.2021.0083.

A Link Between Cardiovascular Risk Management and Alzheimer Disease Is Still Elusive

Affiliations
Comment

A Link Between Cardiovascular Risk Management and Alzheimer Disease Is Still Elusive

Susan M Landau et al. JAMA Neurol. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest Disclosures: Dr Landau reports grants U19 AG024904, R01 MH098062, R01 AG062689, and R01 AG062542 from National Institutes of Health and W81XWH-13-1-0259 from the US Department of Defense. No other disclosures were reported.

Comment on

References

    1. Sperling R, Henley D, Aisen PS, et al. Findings of efficacy, safety, and biomarker outcomes of atabecestat in preclinical Alzheimer disease: a truncated randomized phase 2b/3 clinical trial. JAMA Neurol. Published online January 19, 2021. doi:10.1001/jamaneurol.2020.4857 - DOI - PMC - PubMed
    1. Knopman DS, Jones DT, Greicius MD. Failure to demonstrate efficacy of aducanumab: an analysis of the EMERGE and ENGAGE trials as reported by Biogen, December 2019. Alzheimer’s Dement. Published online November 1, 2020.. doi:10.1002/alz.12213 - DOI - PubMed
    1. Ngandu T, Lehtisalo J, Solomon A, et al. A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial. Lancet. 2015;385(9984):2255–2263. doi:10.1016/S0140-6736(15)60461-5 - DOI - PubMed
    1. Wright JT Jr, Williamson JD, Whelton PK, et al.; SPRINT Research Group. A randomized trial of intensive versus standard blood-pressure control. N Engl J Med. 2015;373(22):2103–2116. doi:10.1056/NEJMoa1511939 - DOI - PMC - PubMed
    1. Williamson JD, Pajewski NM, Auchus AP, et al.; SPRINT MIND Investigators for the SPRINT Research Group. Effect of intensive vs standard blood pressure control on probable dementia: a randomized clinical trial. JAMA. 2019;321(6):553–561. doi:10.1001/jama.2018.21442 - DOI - PMC - PubMed